The role of parvovirus B19 in the pathogenesis of giant cell arteritis: A preliminary evaluation

Sherine E. Gabriel, Mark Espy, Dean D. Erdman, Johannes Bjornsson, Thomas F. Smith, Gene G. Hunder

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Objective. To determine whether parvovirus B19 DNA is more likely to be present in the temporal arteries of patients with giant cell arteritis (GCA) than in the temporal arteries of control subjects. Methods. We prospectively examined temporal artery biopsy (TAB) tissue from 50 consecutive patients presenting for TAB for the presence of B19 DNA using the polymerase chain reaction (PCR). Clinical and demographic information was obtained from the patients' medical records. A separate PCR analysis of 30 original tissue specimens was conducted at the Centers for Disease Control and Prevention (CDC) using primers directed toward another target sequence in the nonstructural coding area of B19. Results. The 50 patients had an average age of 70.8 years; 27 (54%) were female, Amplicons for human β-globulin, but not for cytomegalovirus, were produced for all tissue samples. The PCR results for B19 agreed in 29 of 30 samples tested by our institution and by the CDC (97% agreement; κ = 0.9). A comparison of the B19 DNA analysis and the results of TAB indicated a statistically significant association between histologic evidence of GCA and the presence of B19 DNA in TAB tissue (χ2 = 10.38, P = 0.0013). Conclusion. These findings suggest that B19 may play a role in the pathogenesis of GCA.

Original languageEnglish (US)
Pages (from-to)1255-1258
Number of pages4
JournalArthritis and rheumatism
Volume42
Issue number6
DOIs
StatePublished - Jun 1 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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