The role of parametric linkage methods in complex trait analyses using microsatellites

Michael D. Badzioch, Ellen L. Goode, Gail P. Jarvik

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Many investigators of complexly inherited familial traits bypass classical segregation analysis to perform model-free genome-wide linkage scans. Because model-based or parametric linkage analysis may be the most powerful means to localize genes when a model can be approximated, model-free statistics may result in a loss of power to detect linkage. We performed limited segregation analyses on the electrophysiological measurements that have been collected for the Collaborative Study on the Genetics of Alcoholism. The resulting models are used in wholegenome scans. Four genomic regions provided a model-based LOD > 2 and only 3 of these were detected (p < 0.05) by a model-free approach. We conclude that parametric methods, using even over-simplified models of complex phenotypes, may complement nonparametric methods and decrease false positives.

Original languageEnglish (US)
Article numberS48
JournalBMC genetics
Volume6
Issue numberSUPPL.1
DOIs
StatePublished - Dec 30 2005

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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