Abstract
Heart failure is a clinical syndrome associated with progressive cardiac, vascular, and renal dysfunction. Regardless of the initial injury, investigations have demonstrated that neurohormones play an important role in the complex multiorgan and cellular adaptations. Natriuretic peptides play a key role in this process, antagonizing the actions of the renin-angiotensin-aldosterone system, thus promoting vasodilatation and natriuresis. Other important physiologic properties of the natriuretic peptides are prolusitropic, sympathoinhibitory, antiproliferative, anti-ischemic, anti-inflammatory, and antioxidative. Administering exogenous natriuretic peptide is a US Food and Drug Administration-approved therapy for patients with advanced decompensated congestive heart failure. Also, measuring natriuretic peptide levels has diagnostic and prognostic value. More studies are needed to define the full potential of this unique family of endogenous peptides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 182-189 |
| Number of pages | 8 |
| Journal | Current Cardiology Reports |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2008 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The role of natriuretic peptides in heart failure. / Correa de Sa, Daniel D.; Chen, Horng Haur.
In: Current Cardiology Reports, Vol. 10, No. 3, 2008, p. 182-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of natriuretic peptides in heart failure
AU - Correa de Sa, Daniel D.
AU - Chen, Horng Haur
PY - 2008
Y1 - 2008
N2 - Heart failure is a clinical syndrome associated with progressive cardiac, vascular, and renal dysfunction. Regardless of the initial injury, investigations have demonstrated that neurohormones play an important role in the complex multiorgan and cellular adaptations. Natriuretic peptides play a key role in this process, antagonizing the actions of the renin-angiotensin-aldosterone system, thus promoting vasodilatation and natriuresis. Other important physiologic properties of the natriuretic peptides are prolusitropic, sympathoinhibitory, antiproliferative, anti-ischemic, anti-inflammatory, and antioxidative. Administering exogenous natriuretic peptide is a US Food and Drug Administration-approved therapy for patients with advanced decompensated congestive heart failure. Also, measuring natriuretic peptide levels has diagnostic and prognostic value. More studies are needed to define the full potential of this unique family of endogenous peptides.
AB - Heart failure is a clinical syndrome associated with progressive cardiac, vascular, and renal dysfunction. Regardless of the initial injury, investigations have demonstrated that neurohormones play an important role in the complex multiorgan and cellular adaptations. Natriuretic peptides play a key role in this process, antagonizing the actions of the renin-angiotensin-aldosterone system, thus promoting vasodilatation and natriuresis. Other important physiologic properties of the natriuretic peptides are prolusitropic, sympathoinhibitory, antiproliferative, anti-ischemic, anti-inflammatory, and antioxidative. Administering exogenous natriuretic peptide is a US Food and Drug Administration-approved therapy for patients with advanced decompensated congestive heart failure. Also, measuring natriuretic peptide levels has diagnostic and prognostic value. More studies are needed to define the full potential of this unique family of endogenous peptides.
UR - http://www.scopus.com/inward/record.url?scp=45849110678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45849110678&partnerID=8YFLogxK
U2 - 10.1007/s11886-008-0032-2
DO - 10.1007/s11886-008-0032-2
M3 - Article
C2 - 18489861
AN - SCOPUS:45849110678
VL - 10
SP - 182
EP - 189
JO - Current Cardiology Reports
JF - Current Cardiology Reports
SN - 1523-3782
IS - 3
ER -