TY - JOUR
T1 - The role of myoneural and luminal continuity in the coordination of canine gastroduodenal patterns of motility
AU - Tanaka, Masao
AU - Dalton, Rory R.
AU - Smith, C. Daniel
AU - Van Lier Ribbink, Jeffrey A.
AU - Sarr, Michael G.
N1 - Funding Information:
1 Supported by an NIH Digestive Diseases Core Center (USPHS NIH Grant DK34988), an NIH Grant R01 DK39337 (M.G.S.), and the Ethicon Corporation. ’ Parts of this work were presented at the American Motility Society on October 3, 1988, in Asilomar, California, and are published in abstract form in Gastroenterology 96: 891, 1988. s To whom reprint requests should be addressed at Gastroenterology Research Unit, Mayo Clinic, 200 First Street S. W., Rochester, MN 55905.
PY - 1992/12
Y1 - 1992/12
N2 - Our aim was to determine the role of intrinsic myoneural and enteric luminal continuity in the coordination of gastric and duodenal motility patterns. Three groups of dogs were prepared: five dogs with an intact gastrointestinal tract served as a Control group; four dogs had transection and reanastomosis of the duodenum 0.5 cm distal to the pylorus (Pyloric Transection group); and seven dogs had identical proximal duodenal transection, but with oversewing of duodenum and pylorojejunostomy to a Roux-en-Y limb (Roux-en-Y group). In the Control and Pyloric Transection groups, the gastric and intestinal MMCs were similar in appearance, the cycle durations (x ± SEM) were not different (134 ± 19 vs 111 ± 26 min, respectively; P > 0.05), and the times between the start of gastric and duodenal Phase III (gastroduodenal latency) were similar (6 ± 1 vs 10 ± 3 min; P > 0.05). In the Roux-en-Y group, MMCs also occurred in six of seven dogs but tended to have a longer cycle duration (176 ± 19 min) and a more variable gastroduodenal latency (23 ± 15 min). Plasma motilin concentration, measured only in the Roux-en-Y group, was greater during Phase III in the stomach and duodenum than during Phases I or II (P < 0.05). Feeding inhibited the gastric and duodenal MMCs in all groups, but the duodenal MMC returned earlier in the Roux-en-Y group. The Roux-en-Y jejunal limb exhibited a postprandial pattern in only seven of 14 studies. Luminal continuity and possibly plasma motilin concentration, but not necessarily intrinsic myoneural continuity, appear important in regulating temporal coordination of gastric and duodenal motor patterns during fasting and after feeding.
AB - Our aim was to determine the role of intrinsic myoneural and enteric luminal continuity in the coordination of gastric and duodenal motility patterns. Three groups of dogs were prepared: five dogs with an intact gastrointestinal tract served as a Control group; four dogs had transection and reanastomosis of the duodenum 0.5 cm distal to the pylorus (Pyloric Transection group); and seven dogs had identical proximal duodenal transection, but with oversewing of duodenum and pylorojejunostomy to a Roux-en-Y limb (Roux-en-Y group). In the Control and Pyloric Transection groups, the gastric and intestinal MMCs were similar in appearance, the cycle durations (x ± SEM) were not different (134 ± 19 vs 111 ± 26 min, respectively; P > 0.05), and the times between the start of gastric and duodenal Phase III (gastroduodenal latency) were similar (6 ± 1 vs 10 ± 3 min; P > 0.05). In the Roux-en-Y group, MMCs also occurred in six of seven dogs but tended to have a longer cycle duration (176 ± 19 min) and a more variable gastroduodenal latency (23 ± 15 min). Plasma motilin concentration, measured only in the Roux-en-Y group, was greater during Phase III in the stomach and duodenum than during Phases I or II (P < 0.05). Feeding inhibited the gastric and duodenal MMCs in all groups, but the duodenal MMC returned earlier in the Roux-en-Y group. The Roux-en-Y jejunal limb exhibited a postprandial pattern in only seven of 14 studies. Luminal continuity and possibly plasma motilin concentration, but not necessarily intrinsic myoneural continuity, appear important in regulating temporal coordination of gastric and duodenal motor patterns during fasting and after feeding.
UR - http://www.scopus.com/inward/record.url?scp=0027052502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027052502&partnerID=8YFLogxK
U2 - 10.1016/0022-4804(92)90259-3
DO - 10.1016/0022-4804(92)90259-3
M3 - Article
C2 - 1494292
AN - SCOPUS:0027052502
SN - 0022-4804
VL - 53
SP - 588
EP - 595
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 6
ER -