TY - JOUR
T1 - The role of microRNAs in human liver cancers
AU - Braconi, Chiara
AU - Henry, Jon C.
AU - Kogure, Takayuki
AU - Schmittgen, Thomas
AU - Patel, Tushar
PY - 2011/12
Y1 - 2011/12
N2 - Hepatocellular carcinoma (HCC) is a primary malignancy of the liver of global importance. Recent studies of the expression and role of microRNA (miRNA) in HCC are providing new insights into disease pathogenesis. In addition, therapeutic efforts targeting specific miRNAs are being evaluated in animal models of HCC. The potential of miRNAs as biomarkers of disease or prognostic markers is being explored. Herein, we review studies of miRNA expression in human HCC, and discuss recent advances in knowledge about the involvement and role of selected miRNAs in disease pathogenesis, as biomarkers, or as therapeutic targets for HCC.
AB - Hepatocellular carcinoma (HCC) is a primary malignancy of the liver of global importance. Recent studies of the expression and role of microRNA (miRNA) in HCC are providing new insights into disease pathogenesis. In addition, therapeutic efforts targeting specific miRNAs are being evaluated in animal models of HCC. The potential of miRNAs as biomarkers of disease or prognostic markers is being explored. Herein, we review studies of miRNA expression in human HCC, and discuss recent advances in knowledge about the involvement and role of selected miRNAs in disease pathogenesis, as biomarkers, or as therapeutic targets for HCC.
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U2 - 10.1053/j.seminoncol.2011.08.001
DO - 10.1053/j.seminoncol.2011.08.001
M3 - Article
C2 - 22082761
AN - SCOPUS:81155138127
SN - 0093-7754
VL - 38
SP - 752
EP - 763
JO - Seminars in oncology
JF - Seminars in oncology
IS - 6
ER -