The role of microRNAs in human liver cancers

Chiara Braconi, Jon C. Henry, Takayuki Kogure, Thomas Schmittgen, Tushar C Patel

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver of global importance. Recent studies of the expression and role of microRNA (miRNA) in HCC are providing new insights into disease pathogenesis. In addition, therapeutic efforts targeting specific miRNAs are being evaluated in animal models of HCC. The potential of miRNAs as biomarkers of disease or prognostic markers is being explored. Herein, we review studies of miRNA expression in human HCC, and discuss recent advances in knowledge about the involvement and role of selected miRNAs in disease pathogenesis, as biomarkers, or as therapeutic targets for HCC.

Original languageEnglish (US)
Pages (from-to)752-763
Number of pages12
JournalSeminars in Oncology
Volume38
Issue number6
DOIs
StatePublished - Dec 2011

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Liver Neoplasms
MicroRNAs
Hepatocellular Carcinoma
Biomarkers
Animal Models
Liver
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

The role of microRNAs in human liver cancers. / Braconi, Chiara; Henry, Jon C.; Kogure, Takayuki; Schmittgen, Thomas; Patel, Tushar C.

In: Seminars in Oncology, Vol. 38, No. 6, 12.2011, p. 752-763.

Research output: Contribution to journalArticle

Braconi, C, Henry, JC, Kogure, T, Schmittgen, T & Patel, TC 2011, 'The role of microRNAs in human liver cancers', Seminars in Oncology, vol. 38, no. 6, pp. 752-763. https://doi.org/10.1053/j.seminoncol.2011.08.001
Braconi, Chiara ; Henry, Jon C. ; Kogure, Takayuki ; Schmittgen, Thomas ; Patel, Tushar C. / The role of microRNAs in human liver cancers. In: Seminars in Oncology. 2011 ; Vol. 38, No. 6. pp. 752-763.
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