TY - JOUR
T1 - The role of microRNA-34 family in Alzheimer's disease
T2 - A potential molecular link between neurodegeneration and metabolic disorders
AU - Bazrgar, Maryam
AU - Khodabakhsh, Pariya
AU - Prudencio, Mercedes
AU - Mohagheghi, Fatemeh
AU - Ahmadiani, Abolhassan
N1 - Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Growing evidence indicates that overexpression of the microRNA-34 (miR-34) family in the brain may play a crucial role in Alzheimer's disease (AD) pathogenesis by targeting and downregulating genes associated with neuronal survival, synapse formation and plasticity, Aβ clearance, mitochondrial function, antioxidant defense system, and energy metabolism. Additionally, elevated levels of the miR-34 family in the liver and pancreas promote the development of metabolic syndromes (MetS), such as diabetes and obesity. Importantly, MetS represent a well-documented risk factor for sporadic AD. This review focuses on the recent findings regarding the role of the miR-34 family in the pathogenesis of AD and MetS, and proposes miR-34 as a potential molecular link between both disorders. A comprehensive understanding of the functional roles of miR-34 family in the molecular and cellular pathogenesis of AD brains may lead to the discovery of a breakthrough treatment strategy for this disease.
AB - Growing evidence indicates that overexpression of the microRNA-34 (miR-34) family in the brain may play a crucial role in Alzheimer's disease (AD) pathogenesis by targeting and downregulating genes associated with neuronal survival, synapse formation and plasticity, Aβ clearance, mitochondrial function, antioxidant defense system, and energy metabolism. Additionally, elevated levels of the miR-34 family in the liver and pancreas promote the development of metabolic syndromes (MetS), such as diabetes and obesity. Importantly, MetS represent a well-documented risk factor for sporadic AD. This review focuses on the recent findings regarding the role of the miR-34 family in the pathogenesis of AD and MetS, and proposes miR-34 as a potential molecular link between both disorders. A comprehensive understanding of the functional roles of miR-34 family in the molecular and cellular pathogenesis of AD brains may lead to the discovery of a breakthrough treatment strategy for this disease.
KW - Alzheimer's disease
KW - Metabolic syndrome
KW - MiR-34 family
UR - http://www.scopus.com/inward/record.url?scp=85112491734&partnerID=8YFLogxK
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U2 - 10.1016/j.phrs.2021.105805
DO - 10.1016/j.phrs.2021.105805
M3 - Review article
C2 - 34371173
AN - SCOPUS:85112491734
SN - 1043-6618
VL - 172
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 105805
ER -