The role of microbiome in rheumatoid arthritis treatment

Rahul Bodkhe, Baskar Balakrishnan, Veena Taneja

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Rheumatoid arthritis (RA) is an autoimmune disorder with multifactorial etiology; both genetic and environmental factors are known to be involved in pathogenesis. Treatment with disease-modifying antirheumatic drugs (DMARDs) plays an essential role in controlling disease progression and symptoms. DMARDs have immunomodulatory properties and suppress immune response by interfering in various pro-inflammatory pathways. Recent evidence has shown that the gut microbiota directly and indirectly modulates the host immune system. RA has been associated with dysbiosis of the gut microbiota. Patients with RA treated with DMARDs show partial restoration of eubiotic gut microbiome. Hence, it is essential to understand the impact of DMARDs on the microbial composition and its consequent influences on the host immune system to identify novel therapies for RA. In this review, we discuss the importance of antirheumatic-drug-induced host microbiota modulations and possible probiotics that can generate eubiosis.

Original languageEnglish (US)
JournalTherapeutic Advances in Musculoskeletal Disease
Volume11
DOIs
StatePublished - 2019

Keywords

  • Disease-modifying antirheumatic drugs
  • Gut microbiota
  • Immune modulation
  • Microbial modulation
  • Probiotics
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine

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