The role of lipoprotein A-I and lipoprotein A-I/A-II in predicting coronary artery disease

T. O'Brien, T. T. Nguyen, B. J. Hallaway, D. Hodge, K. Bailey, D. Holmes, B. A. Kottke

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The aim of this study was to examine the role of HDL subparticles with apolipoprotein (apo) A-I alone (LpA-I) and with apoA-I and apoA-II (LpA-I/A-II) in predicting coronary artery disease. Concentrations of these HDL subparticles were compared in 184 subjects with angiographically confirmed significant coronary artery disease (> 50% stenosis of at least one vessel) and 191 age- and sex-matched control subjects without clinical coronary artery disease. LpA-I and LpA-I/A-II were measured with magnetic beads coated with anti-apoA-II antibodies to separate particles containing apoA-II from plasma. Total plasma cholesterol and triglyceride levels were similar in both groups. Although subjects with coronary artery disease had lower HDL cholesterol, plasma apoA-I, LpA-I, and LpA-I/A-II than age- and sex-matched control subjects without coronary artery disease, plasma apoA-I was the best predictor of coronary artery disease. In conclusion, LpA-I and LpA-I/A-II are lower in subjects with coronary artery disease but do not add to plasma apoA-I in predicting the presence of coronary artery disease.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalArteriosclerosis, thrombosis, and vascular biology
Volume15
Issue number2
DOIs
StatePublished - Feb 1995

Keywords

  • HDL
  • coronary artery disease
  • lipids
  • lipoproteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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