Abstract
Fifty patients with carcinoma of the esophagus were entered in a randomized pilot study to test the efficacy of intraluminal radiotherapy (ILRT) and concurrent 5‐fluorouracil (5‐FU) infusion. The median age was 65 years, with 80% having middle third lesions; in 62%, the lesions were longer than 5 cm. After external beam therapy of 50 Gy in 5 weeks, patients were randomized to receive chemotherapy. Significant improvement in dysphagia was recorded in 76% patients with complete response in 47 cases ranging from 6 to 27 months. The overall survival at 2 years was 15% with ILRT alone versus 22% with ILRT plus 5‐FU infusion.
Original language | English (US) |
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Pages (from-to) | 155-160 |
Number of pages | 6 |
Journal | Journal of Surgical Oncology |
Volume | 47 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1991 |
Keywords
- chemotherapy
- complications
- randomized radiation therapy
- results
ASJC Scopus subject areas
- Surgery
- Oncology