The role of intraluminal radiotherapy and concurrent 5‐fluorouracil infusion in the management of carcinoma esophagus: A pilot study

Ketayun A. Dinshaw, Vinay Sharma, Anil M. Pendse, Champat S. Telang, Shanti Swaroop Vege, Mohandas K. Malliat, Raman Deshpande, Prafulla B. Desai

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Fifty patients with carcinoma of the esophagus were entered in a randomized pilot study to test the efficacy of intraluminal radiotherapy (ILRT) and concurrent 5‐fluorouracil (5‐FU) infusion. The median age was 65 years, with 80% having middle third lesions; in 62%, the lesions were longer than 5 cm. After external beam therapy of 50 Gy in 5 weeks, patients were randomized to receive chemotherapy. Significant improvement in dysphagia was recorded in 76% patients with complete response in 47 cases ranging from 6 to 27 months. The overall survival at 2 years was 15% with ILRT alone versus 22% with ILRT plus 5‐FU infusion.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalJournal of Surgical Oncology
Volume47
Issue number3
DOIs
StatePublished - Jul 1991

Keywords

  • chemotherapy
  • complications
  • randomized radiation therapy
  • results

ASJC Scopus subject areas

  • Surgery
  • Oncology

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