Abstract
Insulin-like growth factor I (IGF-I) exerts pleiotropic effects on mammalian cells via stimulation of its receptor (IGF-IR), a receptor tyrosine kinase. In vivo, IGF-I acts both as a local tissue growth factor and as a circulating hormone. In oncological research, IGF-I has received increased attention as the activated IGF-I/IGF-IR system displays mitogeneic, transforming, and anti-apoptotic properties in various cell types by stimulating distinct intracellular signaling pathways. Recent data suggest that the anti-apoptotic effect of IGF-I may mediate decreased sensitivity to chemotherapeutic drugs in vitro and in vivo. Thus, targeting the IGF-I/IGF- IR system could serve as an approach to overcome clinical drug resistance in certain tumors.
Original language | English (US) |
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Pages (from-to) | 166-173 |
Number of pages | 8 |
Journal | Journal of Cancer Research and Clinical Oncology |
Volume | 125 |
Issue number | 3-4 |
DOIs | |
State | Published - 1999 |
Keywords
- Apoptosis
- IGF
- Signaling
- Transformation Chemosensitivity
ASJC Scopus subject areas
- Oncology
- Cancer Research