The role of insulin-like growth factor I and its receptor in cell growth, transformation, apoptosis, and chemoresistance in solid tumors

A. Grothey, W. Voigt, C. Schöber, T. Müller, W. Dempke, H. J. Schmoll

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Insulin-like growth factor I (IGF-I) exerts pleiotropic effects on mammalian cells via stimulation of its receptor (IGF-IR), a receptor tyrosine kinase. In vivo, IGF-I acts both as a local tissue growth factor and as a circulating hormone. In oncological research, IGF-I has received increased attention as the activated IGF-I/IGF-IR system displays mitogeneic, transforming, and anti-apoptotic properties in various cell types by stimulating distinct intracellular signaling pathways. Recent data suggest that the anti-apoptotic effect of IGF-I may mediate decreased sensitivity to chemotherapeutic drugs in vitro and in vivo. Thus, targeting the IGF-I/IGF- IR system could serve as an approach to overcome clinical drug resistance in certain tumors.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalJournal of Cancer Research and Clinical Oncology
Volume125
Issue number3-4
DOIs
StatePublished - Apr 21 1999

Keywords

  • Apoptosis
  • IGF
  • Signaling
  • Transformation Chemosensitivity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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