The role of IL-17 in the association between pneumococcal pneumonia and allergic sensitization

Hongxia Zhao, Cheol In Kang, Mark S. Rouse, Robin Patel, Hirohito Kita, Young J Juhn

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Abstract

Interleukin- (IL-) 17 is important in the development of asthma and host defense against pneumococci. We determined the role of IL-17 in the risk of pneumococcal pneumonia. We challenged mice intranasally with a bioluminescent Streptococcus pneumoniae strain after sensitization and challenge with ovalbumin (OVA). We measured the levels of cytokines, including IL-17 (pg/mL), in the lung homogenate in experimental mice with and without OVA sensitization/ challenge, as well as those with and without pneumococcal pneumonia. IL-17 levels were significantly lower in OVA-sensitized/challenged mice (9.69 ± 1.49), compared to the control mice (20.92 ± 1.82, P < 0.001). In our overall analysis, including IL-4 and IL-17 levels and OVA sensitization/ challenge, IL-4 levels (OR: 81.9, 95%CI: 4.3-1523 per increment of 1.0pg/mL, P = 0.003) were more significant than IL-17 levels (OR: 1.1, 95%CI: 1.03-1.17 per increment of 1.0pg/mL, P = 0.003) in determining the risk of pneumococcal pneumonia. IL-17 levels result in a much smaller impact on the risk for pneumococcal pneumonia, compared to IL-4 levels.

Original languageEnglish (US)
Article number709509
JournalInternational Journal of Microbiology
DOIs
StatePublished - 2011

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Pneumococcal Pneumonia
Interleukin-17
Ovalbumin
Interleukin-4
Streptococcus pneumoniae
Asthma
Cytokines
Lung

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

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title = "The role of IL-17 in the association between pneumococcal pneumonia and allergic sensitization",
abstract = "Interleukin- (IL-) 17 is important in the development of asthma and host defense against pneumococci. We determined the role of IL-17 in the risk of pneumococcal pneumonia. We challenged mice intranasally with a bioluminescent Streptococcus pneumoniae strain after sensitization and challenge with ovalbumin (OVA). We measured the levels of cytokines, including IL-17 (pg/mL), in the lung homogenate in experimental mice with and without OVA sensitization/ challenge, as well as those with and without pneumococcal pneumonia. IL-17 levels were significantly lower in OVA-sensitized/challenged mice (9.69 ± 1.49), compared to the control mice (20.92 ± 1.82, P < 0.001). In our overall analysis, including IL-4 and IL-17 levels and OVA sensitization/ challenge, IL-4 levels (OR: 81.9, 95{\%}CI: 4.3-1523 per increment of 1.0pg/mL, P = 0.003) were more significant than IL-17 levels (OR: 1.1, 95{\%}CI: 1.03-1.17 per increment of 1.0pg/mL, P = 0.003) in determining the risk of pneumococcal pneumonia. IL-17 levels result in a much smaller impact on the risk for pneumococcal pneumonia, compared to IL-4 levels.",
author = "Hongxia Zhao and Kang, {Cheol In} and Rouse, {Mark S.} and Robin Patel and Hirohito Kita and Juhn, {Young J}",
year = "2011",
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language = "English (US)",
journal = "International Journal of Microbiology",
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AU - Zhao, Hongxia

AU - Kang, Cheol In

AU - Rouse, Mark S.

AU - Patel, Robin

AU - Kita, Hirohito

AU - Juhn, Young J

PY - 2011

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AB - Interleukin- (IL-) 17 is important in the development of asthma and host defense against pneumococci. We determined the role of IL-17 in the risk of pneumococcal pneumonia. We challenged mice intranasally with a bioluminescent Streptococcus pneumoniae strain after sensitization and challenge with ovalbumin (OVA). We measured the levels of cytokines, including IL-17 (pg/mL), in the lung homogenate in experimental mice with and without OVA sensitization/ challenge, as well as those with and without pneumococcal pneumonia. IL-17 levels were significantly lower in OVA-sensitized/challenged mice (9.69 ± 1.49), compared to the control mice (20.92 ± 1.82, P < 0.001). In our overall analysis, including IL-4 and IL-17 levels and OVA sensitization/ challenge, IL-4 levels (OR: 81.9, 95%CI: 4.3-1523 per increment of 1.0pg/mL, P = 0.003) were more significant than IL-17 levels (OR: 1.1, 95%CI: 1.03-1.17 per increment of 1.0pg/mL, P = 0.003) in determining the risk of pneumococcal pneumonia. IL-17 levels result in a much smaller impact on the risk for pneumococcal pneumonia, compared to IL-4 levels.

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