The role of IDH1 mutated tumour cells in secondary glioblastomas: An evolutionary game theoretical view

David Basanta, Jacob G. Scott, Russ Rockne, Kristin Swanson, Alexander R A Anderson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Recent advances in clinical medicine have elucidated two significantly different subtypes of which carry very different prognoses, both defined by mutations in isocitrate dehydrogenase-1 (IDH-1). The mechanistic consequences of this mutation have not yet been fully clarified, with conflicting opinions existing in the literature; however, IDH-1 mutation may be used as a surrogate marker to distinguish between primary and secondary glioblastoma multiforme (sGBM) from malignant progression of a lower grade glioma. We develop a mathematical model of IDH-1 mutated secondary glioblastoma using evolutionary game theory to investigate the interactions between four different phenotypic populations within the tumor: autonomous growth, invasive, glycolytic, and the hybrid invasive/glycolytic cells. Our model recapitulates glioblastoma behavior well and is able to reproduce two recent experimental findings, as well as make novel predictions concerning the rate of invasive growth as a function of vascularity, and fluctuations in the proportions of phenotypic populations that a glioblastoma will experience under different microenvironmental constraints.

Original languageEnglish (US)
Article number015016
JournalPhysical Biology
Volume8
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Glioblastoma
Isocitrate Dehydrogenase
Mutation
Neoplasms
Game Theory
Clinical Medicine
Growth
Glioma
Population
Theoretical Models
Biomarkers

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Structural Biology

Cite this

The role of IDH1 mutated tumour cells in secondary glioblastomas : An evolutionary game theoretical view. / Basanta, David; Scott, Jacob G.; Rockne, Russ; Swanson, Kristin; Anderson, Alexander R A.

In: Physical Biology, Vol. 8, No. 1, 015016, 2011.

Research output: Contribution to journalArticle

Basanta, David ; Scott, Jacob G. ; Rockne, Russ ; Swanson, Kristin ; Anderson, Alexander R A. / The role of IDH1 mutated tumour cells in secondary glioblastomas : An evolutionary game theoretical view. In: Physical Biology. 2011 ; Vol. 8, No. 1.
@article{4f894e70229e47f39e0778e0e7af449d,
title = "The role of IDH1 mutated tumour cells in secondary glioblastomas: An evolutionary game theoretical view",
abstract = "Recent advances in clinical medicine have elucidated two significantly different subtypes of which carry very different prognoses, both defined by mutations in isocitrate dehydrogenase-1 (IDH-1). The mechanistic consequences of this mutation have not yet been fully clarified, with conflicting opinions existing in the literature; however, IDH-1 mutation may be used as a surrogate marker to distinguish between primary and secondary glioblastoma multiforme (sGBM) from malignant progression of a lower grade glioma. We develop a mathematical model of IDH-1 mutated secondary glioblastoma using evolutionary game theory to investigate the interactions between four different phenotypic populations within the tumor: autonomous growth, invasive, glycolytic, and the hybrid invasive/glycolytic cells. Our model recapitulates glioblastoma behavior well and is able to reproduce two recent experimental findings, as well as make novel predictions concerning the rate of invasive growth as a function of vascularity, and fluctuations in the proportions of phenotypic populations that a glioblastoma will experience under different microenvironmental constraints.",
author = "David Basanta and Scott, {Jacob G.} and Russ Rockne and Kristin Swanson and Anderson, {Alexander R A}",
year = "2011",
doi = "10.1088/1478-3975/8/1/015016",
language = "English (US)",
volume = "8",
journal = "Physical Biology",
issn = "1478-3967",
publisher = "IOP Publishing Ltd.",
number = "1",

}

TY - JOUR

T1 - The role of IDH1 mutated tumour cells in secondary glioblastomas

T2 - An evolutionary game theoretical view

AU - Basanta, David

AU - Scott, Jacob G.

AU - Rockne, Russ

AU - Swanson, Kristin

AU - Anderson, Alexander R A

PY - 2011

Y1 - 2011

N2 - Recent advances in clinical medicine have elucidated two significantly different subtypes of which carry very different prognoses, both defined by mutations in isocitrate dehydrogenase-1 (IDH-1). The mechanistic consequences of this mutation have not yet been fully clarified, with conflicting opinions existing in the literature; however, IDH-1 mutation may be used as a surrogate marker to distinguish between primary and secondary glioblastoma multiforme (sGBM) from malignant progression of a lower grade glioma. We develop a mathematical model of IDH-1 mutated secondary glioblastoma using evolutionary game theory to investigate the interactions between four different phenotypic populations within the tumor: autonomous growth, invasive, glycolytic, and the hybrid invasive/glycolytic cells. Our model recapitulates glioblastoma behavior well and is able to reproduce two recent experimental findings, as well as make novel predictions concerning the rate of invasive growth as a function of vascularity, and fluctuations in the proportions of phenotypic populations that a glioblastoma will experience under different microenvironmental constraints.

AB - Recent advances in clinical medicine have elucidated two significantly different subtypes of which carry very different prognoses, both defined by mutations in isocitrate dehydrogenase-1 (IDH-1). The mechanistic consequences of this mutation have not yet been fully clarified, with conflicting opinions existing in the literature; however, IDH-1 mutation may be used as a surrogate marker to distinguish between primary and secondary glioblastoma multiforme (sGBM) from malignant progression of a lower grade glioma. We develop a mathematical model of IDH-1 mutated secondary glioblastoma using evolutionary game theory to investigate the interactions between four different phenotypic populations within the tumor: autonomous growth, invasive, glycolytic, and the hybrid invasive/glycolytic cells. Our model recapitulates glioblastoma behavior well and is able to reproduce two recent experimental findings, as well as make novel predictions concerning the rate of invasive growth as a function of vascularity, and fluctuations in the proportions of phenotypic populations that a glioblastoma will experience under different microenvironmental constraints.

UR - http://www.scopus.com/inward/record.url?scp=79951932661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951932661&partnerID=8YFLogxK

U2 - 10.1088/1478-3975/8/1/015016

DO - 10.1088/1478-3975/8/1/015016

M3 - Article

C2 - 21301070

AN - SCOPUS:79951932661

VL - 8

JO - Physical Biology

JF - Physical Biology

SN - 1478-3967

IS - 1

M1 - 015016

ER -