TY - JOUR
T1 - The role of HTS in drug discovery at the university of michigan
AU - Larsen, Martha J.
AU - Larsen, Scott D.
AU - Fribley, Andrew
AU - Grembecka, Jolanta
AU - Homan, Kristoff
AU - Mapp, Anna
AU - Haak, Andrew
AU - Nikolovska-Coleska, Zaneta
AU - Stuckey, Jeanne A.
AU - Sun, Duxin
AU - Sherman, David H.
PY - 2014/3
Y1 - 2014/3
N2 - High throughput screening (HTS) is an integral part of a highly collaborative approach to drug discovery at the University of Michigan. The HTS lab is one of four core centers that provide services to identify, produce, screen and follow-up on biomedical targets for faculty. Key features of this system are: protein cloning and purification, protein crystallography, small molecule and siRNA HTS, medicinal chemistry and pharmacokinetics. Therapeutic areas that have been targeted include anti-bacterial, metabolic, neurodegenerative, cardiovascular, anti-cancer and anti-viral. The centers work in a coordinated, interactive environment to affordably provide academic investigators with the technology, informatics and expertise necessary for successful drug discovery. This review provides an overview of these centers at the University of Michigan, along with case examples of successful collaborations with faculty.
AB - High throughput screening (HTS) is an integral part of a highly collaborative approach to drug discovery at the University of Michigan. The HTS lab is one of four core centers that provide services to identify, produce, screen and follow-up on biomedical targets for faculty. Key features of this system are: protein cloning and purification, protein crystallography, small molecule and siRNA HTS, medicinal chemistry and pharmacokinetics. Therapeutic areas that have been targeted include anti-bacterial, metabolic, neurodegenerative, cardiovascular, anti-cancer and anti-viral. The centers work in a coordinated, interactive environment to affordably provide academic investigators with the technology, informatics and expertise necessary for successful drug discovery. This review provides an overview of these centers at the University of Michigan, along with case examples of successful collaborations with faculty.
KW - Drug discovery
KW - High throughput screening
KW - Medicinal chemistry
KW - Pharmacokinetics
KW - Protein crystallography
KW - Structural biology
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U2 - 10.2174/1386207317666140109121546
DO - 10.2174/1386207317666140109121546
M3 - Article
C2 - 24409957
AN - SCOPUS:84897994874
SN - 1386-2073
VL - 17
SP - 210
EP - 230
JO - Combinatorial Chemistry and High Throughput Screening
JF - Combinatorial Chemistry and High Throughput Screening
IS - 3
ER -