@article{a085671211d241cdb99f19e7350ac844,
title = "The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity",
abstract = "This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS-CoV-2.",
keywords = "COVID-19, GWAS, HLA, SARS, SARS-CoV-2, alleles, coronavirus, genes, genetic variation, genome-wide association study, immunogenetics, polymorphisms, severe acute respiratory syndrome, single nucleotide, systems biology, vaccine",
author = "Ovsyannikova, {Inna G.} and Haralambieva, {Iana H.} and Crooke, {Stephen N.} and Poland, {Gregory A.} and Kennedy, {Richard B.}",
note = "Funding Information: Dr Poland is the chair of a Safety Evaluation Committee for novel investigational vaccine trials being conducted by Merck Research Laboratories. Dr Poland offers consultative advice on vaccine development to Merck & Co. Inc, Avianax, Adjuvance, Valneva, Medicago, Sanofi Pasteur, GlaxoSmithKline, and Emergent Biosolutions. Drs. Poland and Ovsyannikova hold three patents related to measles and vaccinia peptide research. Dr Kennedy holds a patent on vaccinia peptide research. Dr Kennedy has received funding from Merck Research Laboratories to study waning immunity to measles and mumps after immunization with the MMR‐II vaccine. Drs. Poland, Kennedy, and Ovsyannikova have received grant funding from ICW Ventures for preclinical studies on a peptide‐based COVID‐19 vaccine. All other authors declare no competing financial interests. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with Mayo Clinic Conflict of Interest policies. {\textregistered} Funding Information: We thank Caroline L. Vitse for her editorial assistance. This work was funded in parts by the National Institute of Allergy and Infectious Diseases grant numbers AI132348, AI121054, AI127365. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2020",
month = jul,
day = "1",
doi = "10.1111/imr.12897",
language = "English (US)",
volume = "296",
pages = "205--219",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",
}