Abstract
This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS-CoV-2.
Original language | English (US) |
---|---|
Pages (from-to) | 205-219 |
Number of pages | 15 |
Journal | Immunological Reviews |
Volume | 296 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 2020 |
Keywords
- COVID-19
- GWAS
- HLA
- SARS
- SARS-CoV-2
- alleles
- coronavirus
- genes
- genetic variation
- genome-wide association study
- immunogenetics
- polymorphisms
- severe acute respiratory syndrome
- single nucleotide
- systems biology
- vaccine
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology