The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity

Inna G. Ovsyannikova, Iana H. Haralambieva, Stephen N. Crooke, Gregory A. Poland, Richard B. Kennedy

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS-CoV-2.

Original languageEnglish (US)
Pages (from-to)205-219
Number of pages15
JournalImmunological Reviews
Volume296
Issue number1
DOIs
StatePublished - Jul 1 2020

Keywords

  • COVID-19
  • GWAS
  • HLA
  • SARS
  • SARS-CoV-2
  • alleles
  • coronavirus
  • genes
  • genetic variation
  • genome-wide association study
  • immunogenetics
  • polymorphisms
  • severe acute respiratory syndrome
  • single nucleotide
  • systems biology
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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