The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions

Joseph M. Gaballa, Manuel Bonfim Braga Neto, Guilherme Piovezani Ramos, Adebowale O. Bamidele, Michelle M. Gonzalez, Mary R. Sagstetter, Olga F. Sarmento, William Alvis Faubion

Research output: Contribution to journalReview article

Abstract

T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.

Original languageEnglish (US)
Number of pages1
JournalFrontiers in Immunology
Volume9
DOIs
StatePublished - Jan 1 2018

Fingerprint

Long Noncoding RNA
Epigenomics
Cell Lineage
T-Lymphocytes
Intrinsic Factor
Gene Regulatory Networks
Autoimmunity
Histones
Cell Differentiation
Therapeutics
histone methyltransferase
Neoplasms

Keywords

  • epigenetics
  • EZH2
  • G9a
  • long non-coding RNAs
  • PRC1
  • PRC2
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions. / Gaballa, Joseph M.; Braga Neto, Manuel Bonfim; Ramos, Guilherme Piovezani; Bamidele, Adebowale O.; Gonzalez, Michelle M.; Sagstetter, Mary R.; Sarmento, Olga F.; Faubion, William Alvis.

In: Frontiers in Immunology, Vol. 9, 01.01.2018.

Research output: Contribution to journalReview article

Gaballa, Joseph M. ; Braga Neto, Manuel Bonfim ; Ramos, Guilherme Piovezani ; Bamidele, Adebowale O. ; Gonzalez, Michelle M. ; Sagstetter, Mary R. ; Sarmento, Olga F. ; Faubion, William Alvis. / The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions. In: Frontiers in Immunology. 2018 ; Vol. 9.
@article{1afd566fd0f74aa5950a366c9a96c022,
title = "The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions",
abstract = "T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.",
keywords = "epigenetics, EZH2, G9a, long non-coding RNAs, PRC1, PRC2, T cell",
author = "Gaballa, {Joseph M.} and {Braga Neto}, {Manuel Bonfim} and Ramos, {Guilherme Piovezani} and Bamidele, {Adebowale O.} and Gonzalez, {Michelle M.} and Sagstetter, {Mary R.} and Sarmento, {Olga F.} and Faubion, {William Alvis}",
year = "2018",
month = "1",
day = "1",
doi = "10.3389/fimmu.2018.02955",
language = "English (US)",
volume = "9",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions

AU - Gaballa, Joseph M.

AU - Braga Neto, Manuel Bonfim

AU - Ramos, Guilherme Piovezani

AU - Bamidele, Adebowale O.

AU - Gonzalez, Michelle M.

AU - Sagstetter, Mary R.

AU - Sarmento, Olga F.

AU - Faubion, William Alvis

PY - 2018/1/1

Y1 - 2018/1/1

N2 - T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.

AB - T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.

KW - epigenetics

KW - EZH2

KW - G9a

KW - long non-coding RNAs

KW - PRC1

KW - PRC2

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=85059930027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059930027&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.02955

DO - 10.3389/fimmu.2018.02955

M3 - Review article

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

ER -