The Role of Genetics in IBS

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.

Original languageEnglish (US)
Pages (from-to)45-67
Number of pages23
JournalGastroenterology Clinics of North America
Volume40
Issue number1
DOIs
StatePublished - Mar 2011

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Irritable Bowel Syndrome
Genes

Keywords

  • Complex genetic disease
  • Gene
  • Genetics
  • Irritable bowel syndrome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The Role of Genetics in IBS. / Saito Loftus, Yuri Ann.

In: Gastroenterology Clinics of North America, Vol. 40, No. 1, 03.2011, p. 45-67.

Research output: Contribution to journalArticle

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