The role of functional imaging in radiotherapy planning and management for gynecologic malignancies

Daniel J. Ma; Susan Guo; Shetal N. Shah; Shyam M. Srinivas; Roger M. Macklis

doi:10.1016/j.cpet.2011.02.006

The role of functional imaging in radiotherapy planning and management for gynecologic malignancies

Daniel J. Ma, Susan Guo, Shetal N. Shah, Shyam M. Srinivas, Roger M. Macklis

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

Abstract

FDG-PET and PET/CT have comparable sensitivities in staging primary endometrial lesions as conventional imaging modalities. The sensitivity is low for lymph node staging and is limited by the spatial resolution of PET, which cannot detect microscopic metastatic disease. FDG-PET staging should not replace surgical staging with lymphadenectomy. However, the high NPV of FDG-PET for nodal disease may allow selected patients who are poor surgical candidates to avoid morbidities of lymphadenectomy. FDG-PET is useful for accurately detecting the presence of distant metastases. In addition, FDG uptake can correlate with higher-grade tumors. Larger prospective studies are needed to clarify the role of FDG-PET and PET/CT in the preoperative evaluation of endometrial cancer.

Original language	English (US)
Pages (from-to)	195-205
Number of pages	11
Journal	PET Clinics
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.cpet.2011.02.006
State	Published - Apr 2011

Keywords

Cervical cancer
Endometrial cancer
Functional imaging
Gynecologic malignancies

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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10.1016/j.cpet.2011.02.006

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title = "The role of functional imaging in radiotherapy planning and management for gynecologic malignancies",

abstract = "FDG-PET and PET/CT have comparable sensitivities in staging primary endometrial lesions as conventional imaging modalities. The sensitivity is low for lymph node staging and is limited by the spatial resolution of PET, which cannot detect microscopic metastatic disease. FDG-PET staging should not replace surgical staging with lymphadenectomy. However, the high NPV of FDG-PET for nodal disease may allow selected patients who are poor surgical candidates to avoid morbidities of lymphadenectomy. FDG-PET is useful for accurately detecting the presence of distant metastases. In addition, FDG uptake can correlate with higher-grade tumors. Larger prospective studies are needed to clarify the role of FDG-PET and PET/CT in the preoperative evaluation of endometrial cancer.",

keywords = "Cervical cancer, Endometrial cancer, Functional imaging, Gynecologic malignancies",

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AU - Ma, Daniel J.

AU - Guo, Susan

AU - Shah, Shetal N.

AU - Srinivas, Shyam M.

AU - Macklis, Roger M.

PY - 2011/4

Y1 - 2011/4

N2 - FDG-PET and PET/CT have comparable sensitivities in staging primary endometrial lesions as conventional imaging modalities. The sensitivity is low for lymph node staging and is limited by the spatial resolution of PET, which cannot detect microscopic metastatic disease. FDG-PET staging should not replace surgical staging with lymphadenectomy. However, the high NPV of FDG-PET for nodal disease may allow selected patients who are poor surgical candidates to avoid morbidities of lymphadenectomy. FDG-PET is useful for accurately detecting the presence of distant metastases. In addition, FDG uptake can correlate with higher-grade tumors. Larger prospective studies are needed to clarify the role of FDG-PET and PET/CT in the preoperative evaluation of endometrial cancer.

AB - FDG-PET and PET/CT have comparable sensitivities in staging primary endometrial lesions as conventional imaging modalities. The sensitivity is low for lymph node staging and is limited by the spatial resolution of PET, which cannot detect microscopic metastatic disease. FDG-PET staging should not replace surgical staging with lymphadenectomy. However, the high NPV of FDG-PET for nodal disease may allow selected patients who are poor surgical candidates to avoid morbidities of lymphadenectomy. FDG-PET is useful for accurately detecting the presence of distant metastases. In addition, FDG uptake can correlate with higher-grade tumors. Larger prospective studies are needed to clarify the role of FDG-PET and PET/CT in the preoperative evaluation of endometrial cancer.

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KW - Endometrial cancer

KW - Functional imaging

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The role of functional imaging in radiotherapy planning and management for gynecologic malignancies

Abstract

Keywords

ASJC Scopus subject areas

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