The role of functional imaging in radiotherapy planning and management for gynecologic malignancies

Daniel J. Ma, Susan Guo, Shetal N. Shah, Shyam M. Srinivas, Roger M. Macklis

Research output: Contribution to journalReview article

Abstract

FDG-PET and PET/CT have comparable sensitivities in staging primary endometrial lesions as conventional imaging modalities. The sensitivity is low for lymph node staging and is limited by the spatial resolution of PET, which cannot detect microscopic metastatic disease. FDG-PET staging should not replace surgical staging with lymphadenectomy. However, the high NPV of FDG-PET for nodal disease may allow selected patients who are poor surgical candidates to avoid morbidities of lymphadenectomy. FDG-PET is useful for accurately detecting the presence of distant metastases. In addition, FDG uptake can correlate with higher-grade tumors. Larger prospective studies are needed to clarify the role of FDG-PET and PET/CT in the preoperative evaluation of endometrial cancer.

Original languageEnglish (US)
Pages (from-to)195-205
Number of pages11
JournalPET Clinics
Volume6
Issue number2
DOIs
StatePublished - Apr 2011

Keywords

  • Cervical cancer
  • Endometrial cancer
  • Functional imaging
  • Gynecologic malignancies

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

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