The role of FKBP5 in cancer aetiology and chemoresistance

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs such as rapamycin and cyclosporine. Although FKBP5 shares characteristics with other FKBPs, it also has unique features, especially its role in the regulation of multiple signalling pathways and in tumourigenesis and chemoresistance. In this review, we will focus on the recently discovered role of FKBP5 in cancer aetiology and response to antineoplastic therapy.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalBritish Journal of Cancer
Volume104
Issue number1
DOIs
StatePublished - Jan 4 2011

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Tacrolimus Binding Proteins
Immunophilins
Neoplasms
Sirolimus
Antineoplastic Agents
Cyclosporine
Pharmaceutical Preparations
Therapeutics

Keywords

  • chemoresistance
  • FKBP5
  • immunophilins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The role of FKBP5 in cancer aetiology and chemoresistance. / Li, L.; Lou, Zhenkun; Wang, Liewei M.

In: British Journal of Cancer, Vol. 104, No. 1, 04.01.2011, p. 19-23.

Research output: Contribution to journalArticle

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