The role of complex combination therapy in the treatment of refractory bipolar illness

M. Robert, Mark A. Frye, Gabriele S. Leverich, Kirk D. Denicoff

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

In this article, we present rationales for using complex combination therapy in treatment-refractory bipolar patients and discuss the agents available for use in this therapeutic approach. We review a case example of successful remission that was achievable only with complex combination therapy, and examine its theoretical implications. Practical approaches to devising the optimal complex combination treatment for individual patients are explained, and we look to the development of new methodologies and a more systematic database for decision making in the future.

Original languageEnglish (US)
Pages (from-to)66-86
Number of pages21
JournalCNS Spectrums
Volume3
Issue number5
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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