The role of complement-fixing donor-specific antibodies identified by a C1q assay after heart transplantation

M. Farrero Torres, M. J. Pando, C. Luo, H. Luikart, H. Valantine, K. Khush

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: The development of donor-specific antibodies (DSA) to human leukocyte antigens (HLA) has been associated with acute rejection and allograft failure after heart transplantation. Not all DSA, however, can fix complement. Methods: To determine the association between complement-fixing DSA and heart transplant outcomes, we retrospectively analyzed results obtained using the C1q solid-phase assay that specifically detects complement-fixing DSA in parallel with the standard IgG assay in 121 adult heart transplant recipients. Results: The 52 recipients who developed post-transplant DSA had a higher incidence of acute cellular rejection (58% vs 19%, P <.001) and antibody-mediated rejection (29% vs 7%, P <.001) than the 69 recipients without DSA. The 24 recipients with C1q+ DSA had more antibody-mediated rejection than the 28 recipients with C1q− DSA (46% vs 14%, P =.012), but there was no difference in the incidence of acute cellular rejection between these two groups. Patients with post-transplant DSA had higher mortality than patients with no DSA (29% vs 13%, P =.031), mainly due to increased incidence of acute rejection. No differences in survival were found between recipients with C1q+ DSA and C1q− DSA. Conclusions: Routine monitoring of DSA post-transplant, and their characterization using the C1q assay, may provide prognostic information for acute rejection after heart transplantation.

Original languageEnglish (US)
Article numbere13121
JournalClinical Transplantation
Volume31
Issue number11
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Keywords

  • antibody biology
  • antibody-mediated (ABMR)
  • biopsy
  • graft survival
  • rejection

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Farrero Torres, M., Pando, M. J., Luo, C., Luikart, H., Valantine, H., & Khush, K. (2017). The role of complement-fixing donor-specific antibodies identified by a C1q assay after heart transplantation. Clinical Transplantation, 31(11), [e13121]. https://doi.org/10.1111/ctr.13121