The role of cell-based bioartificial liver therapy in the treatment of fulminant hepatic failure

Scott L. Nyberg, Takakazu Matsushita, Gregory J. Gores, Eileen Hay, Russell H. Wiesner, Alvaro A. Pineda, Dennis A. Gastineau, S. Breanndan Moore, David J. Plevak, Eelco F. Wijdicks, David G. Piepgras, Jeffrey L. Platt, Charles B. Rosen

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Fulminant liver failure (FHF) is associated with a high rate of mortality. Cell-based liver support systems have been developed for the treatment of FHF to prevent the development of potentially life-ending complications such as cerebral edema, intracranial hypertension, and brain herniation. Extracorporeal liver support systems, such as the bioartificial liver (BAL), contain hepatocytes intended to provide auxiliary hepatic function as a bridge to liver transplantation. Clinical trials indicate that the beneficial effects of BAL therapy include a reduction of cerebral edema and intracranial pressure, along with the possibility of spontaneous recovery in some cases. Enhancements to the BAL such as increasing the mass of viable and metabolically active hepatocytes are likely to be associated with greater efficacy in future clinical trials.

Original languageEnglish (US)
Pages (from-to)374-382
Number of pages9
JournalGraft
Volume5
Issue number7
DOIs
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Transplantation

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    Nyberg, S. L., Matsushita, T., Gores, G. J., Hay, E., Wiesner, R. H., Pineda, A. A., Gastineau, D. A., Moore, S. B., Plevak, D. J., Wijdicks, E. F., Piepgras, D. G., Platt, J. L., & Rosen, C. B. (2002). The role of cell-based bioartificial liver therapy in the treatment of fulminant hepatic failure. Graft, 5(7), 374-382. https://doi.org/10.1177/152216202237621