The role of caveolae in the pathophysiology of lung diseases

Michael A. Thompson, Y. S. Prakash, Christina M. Pabelick

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Caveolae are flask-shaped plasma membrane invaginations formed by constitutive caveolin proteins and regulatory cavin proteins. Caveolae harbor a range of signaling components such as receptors, ion channels and regulatory molecules. There is now increasing evidence that caveolins and cavins play an important role in a variety of diseases. However, the mechanisms by which these caveolar proteins affect lung health and disease are still under investigation, with emerging data suggesting complex roles in disease pathophysiology. This review summarizes the current state of understanding of how caveolar proteins contribute to lung structure and function and how their altered expression and/or function can influence lung diseases.

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalExpert Review of Respiratory Medicine
Volume8
Issue number1
DOIs
StatePublished - Feb 1 2014

Keywords

  • COPD
  • asthma
  • caveolae
  • caveolin
  • cavin
  • lung
  • lung injury
  • pulmonary fibrosis
  • pulmonary hypertension

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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