The role of cadherins and catenins in gliomagenesis.

Kaveh Barami, Laura Lewis-Tuffin, Panagiotis Z Anastasiadis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cell-cell adhesion is a crucial process occurring during normal tissue development. Cadherins are calcium-dependent cell-surface adhesion molecules involved in cell-cell adhesion. They reorganize the actin cytoskeleton via interaction with the catenins. Modulation of the cadherin/catenin system plays a role in cell motility. Dysregulation of the cadherin/catenin assembly has been implicated in various cancers. In this review, the authors summarize all studies focusing on the role of cadherins and catenins in glioma formation. With the emergence of recent data regarding gliomas' putative cell of origin, elucidation of the role of cadherins/catenins in gliomagenesis will become important in devising new therapeutic approaches against such deadly cancers.

Original languageEnglish (US)
JournalNeurosurgical Focus
Volume21
Issue number4
StatePublished - 2006
Externally publishedYes

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Catenins
Cadherins
Cell Adhesion
Glioma
Cell Adhesion Molecules
Actin Cytoskeleton
Cell Movement
Neoplasms
Calcium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The role of cadherins and catenins in gliomagenesis. / Barami, Kaveh; Lewis-Tuffin, Laura; Anastasiadis, Panagiotis Z.

In: Neurosurgical Focus, Vol. 21, No. 4, 2006.

Research output: Contribution to journalArticle

Barami, Kaveh ; Lewis-Tuffin, Laura ; Anastasiadis, Panagiotis Z. / The role of cadherins and catenins in gliomagenesis. In: Neurosurgical Focus. 2006 ; Vol. 21, No. 4.
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