The role of brain-derived neurotrophic factor in different animal models of neuropathic pain

Pascal Vanelderen, Tom Rouwette, Tamas Kozicz, Eric Roubos, Jan Van Zundert, Rene Heylen, Kris Vissers

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Even in present day pain therapy, neuropathic pain remains a challenge for clinicians to treat and a challenge for researchers to investigate. Different animal models have been developed to mimic neuropathic pain. Neurotrophins such as nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3 have been studied extensively in these models, yet few review articles concerning brain-derived neurotrophic factor have been published. This article reassesses the literature concerning brain-derived neurotrophic factor expression in the sciatic nerve chronic constriction injury model, the sciatic nerve transection model, the spinal nerve ligation model and the spinal nerve transection model and discusses differences in regulation of brain-derived neurotrophic factor between these models and their causality with neuropathic pain.

Original languageEnglish (US)
JournalEuropean Journal of Pain
Volume14
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Neuralgia
Animal Models
Spinal Nerves
Sciatic Nerve
Neurotrophin 3
Nerve Growth Factors
Nerve Growth Factor
Constriction
Causality
Ligation
Research Personnel
Pain
Wounds and Injuries
Therapeutics

Keywords

  • activating transcription factor 3
  • ATF3
  • BDNF
  • brain-derived neurotrophic factor
  • Brain-derived neurotrophic factor
  • CCI
  • chronic constriction injury
  • DH
  • dorsal horn
  • Dorsal root ganglion
  • dorsal root ganglion
  • DRG
  • ERK
  • extracellular signal-regulated protein kinases
  • i.t.
  • immunoreactive
  • intrathecally
  • IR
  • JNK
  • Jun N-terminal kinase
  • KCC2
  • MAPK
  • mitogen activated protein kinase
  • nerve growth factor
  • neuropeptide Y
  • neurotrophin 3
  • neurotrophin 4
  • neurotrophin 5
  • Neurotrophins
  • NGF
  • NPY
  • NT3
  • NT4
  • NT5
  • p75 neurotrophin receptor
  • P75NTR
  • potassium-chloride co-transporter 2
  • Sciatic nerve
  • SNL
  • SNT
  • Spinal nerve
  • spinal nerve ligation
  • spinal nerve transection

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The role of brain-derived neurotrophic factor in different animal models of neuropathic pain. / Vanelderen, Pascal; Rouwette, Tom; Kozicz, Tamas; Roubos, Eric; Zundert, Jan Van; Heylen, Rene; Vissers, Kris.

In: European Journal of Pain, Vol. 14, No. 5, 01.05.2010.

Research output: Contribution to journalReview article

Vanelderen, Pascal ; Rouwette, Tom ; Kozicz, Tamas ; Roubos, Eric ; Zundert, Jan Van ; Heylen, Rene ; Vissers, Kris. / The role of brain-derived neurotrophic factor in different animal models of neuropathic pain. In: European Journal of Pain. 2010 ; Vol. 14, No. 5.
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