The role of bilateral inferior petrosal sinus sampling in the diagnostic evaluation of Cushing syndrome

Amy Deipolyi; Ali Karaosmanoǧlu; Cicero Habito; Scott Brannan; Stephan Wicky; Joshua Hirsch; Rahmi Oklu

doi:10.4261/1305-3825.DIR.4279-11.0

The role of bilateral inferior petrosal sinus sampling in the diagnostic evaluation of Cushing syndrome

Amy Deipolyi, Ali Karaosmanoǧlu, Cicero Habito, Scott Brannan, Stephan Wicky, Joshua Hirsch, Rahmi Oklu

Diagnostic Radiology

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Bilateral inferior petrosal sinus sampling is the gold standard diagnostic assay in identifying the pituitary source of adrenocorticotropic hormone secretion in Cushing syndrome. The noninvasive assays used in the workup of Cushing syndrome are often misleading or ambiguous, yielding sensitivities of up to only 80%. Inferior petrosal sinus sampling, however, is highly accurate and safe when performed in experienced centers. We review here the historical and technical details of the procedure, with emphasis on the relevant anatomy and a discussion of possible rare complications.

Original language	English (US)
Pages (from-to)	132-138
Number of pages	7
Journal	Diagnostic and Interventional Radiology
Volume	18
Issue number	1
DOIs	https://doi.org/10.4261/1305-3825.DIR.4279-11.0
State	Published - Jan 2012

Keywords

ACTH-secreting pituitary adenoma
Cushing syndrome
Inferior petrosal sinus sampling

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.4261/1305-3825.DIR.4279-11.0

Cite this

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abstract = "Bilateral inferior petrosal sinus sampling is the gold standard diagnostic assay in identifying the pituitary source of adrenocorticotropic hormone secretion in Cushing syndrome. The noninvasive assays used in the workup of Cushing syndrome are often misleading or ambiguous, yielding sensitivities of up to only 80%. Inferior petrosal sinus sampling, however, is highly accurate and safe when performed in experienced centers. We review here the historical and technical details of the procedure, with emphasis on the relevant anatomy and a discussion of possible rare complications.",

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AU - Deipolyi, Amy

AU - Karaosmanoǧlu, Ali

AU - Habito, Cicero

AU - Brannan, Scott

AU - Wicky, Stephan

AU - Hirsch, Joshua

AU - Oklu, Rahmi

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N2 - Bilateral inferior petrosal sinus sampling is the gold standard diagnostic assay in identifying the pituitary source of adrenocorticotropic hormone secretion in Cushing syndrome. The noninvasive assays used in the workup of Cushing syndrome are often misleading or ambiguous, yielding sensitivities of up to only 80%. Inferior petrosal sinus sampling, however, is highly accurate and safe when performed in experienced centers. We review here the historical and technical details of the procedure, with emphasis on the relevant anatomy and a discussion of possible rare complications.

AB - Bilateral inferior petrosal sinus sampling is the gold standard diagnostic assay in identifying the pituitary source of adrenocorticotropic hormone secretion in Cushing syndrome. The noninvasive assays used in the workup of Cushing syndrome are often misleading or ambiguous, yielding sensitivities of up to only 80%. Inferior petrosal sinus sampling, however, is highly accurate and safe when performed in experienced centers. We review here the historical and technical details of the procedure, with emphasis on the relevant anatomy and a discussion of possible rare complications.

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KW - Cushing syndrome

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The role of bilateral inferior petrosal sinus sampling in the diagnostic evaluation of Cushing syndrome

Abstract

Keywords

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