TY - JOUR
T1 - The role of base excision repair in major depressive disorder and bipolar disorder
AU - Kucuker, Mehmet Utku
AU - Ozerdem, Aysegul
AU - Ceylan, Deniz
AU - Cabello-Arreola, Alejandra
AU - Ho, Ada M.C.
AU - Joseph, Boney
AU - Webb, Lauren M.
AU - Croarkin, Paul E.
AU - Frye, Mark A.
AU - Veldic, Marin
N1 - Funding Information:
Paul Croarkin has received research grant support from Pfizer, Inc., Neosync, Inc., and Neuronetics, Inc. He has received supplies and genotyping services from Assurex Health, Inc. for an investigator-initiated study. He has received equipment support from Neuronetics, Inc. and MagVenture, Inc. for investigator-initiated studies. Dr. Croarkin has served as a consultant for Procter & Gamble Company, Myriad Neuroscience, Sunovion, and Engrail Therapeutics.
Funding Information:
We wish to thank to Mayo Clinic librarians for their assistance with the literature search in this paper.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Background: In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders. This systematic review sought to review DNA repair enzymes, with emphasis on the base excision repair (BER), in mood disorders. Methods: We conducted a comprehensive literature search of Ovid MEDLINE® Epub Ahead of Print, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Ovid MEDLINE® Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD. Results: A total of 1364 records were identified. 1352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (single nucleotide polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies. Limitations: All studies were correlational so it was not possible to draw conclusions regarding causality. Conclusion: Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response.
AB - Background: In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders. This systematic review sought to review DNA repair enzymes, with emphasis on the base excision repair (BER), in mood disorders. Methods: We conducted a comprehensive literature search of Ovid MEDLINE® Epub Ahead of Print, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Ovid MEDLINE® Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD. Results: A total of 1364 records were identified. 1352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (single nucleotide polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies. Limitations: All studies were correlational so it was not possible to draw conclusions regarding causality. Conclusion: Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response.
KW - Base excision repair
KW - Bipolar disorder
KW - DNA repair
KW - Major depressive disorder
KW - Oxidative damage
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U2 - 10.1016/j.jad.2022.03.033
DO - 10.1016/j.jad.2022.03.033
M3 - Review article
C2 - 35306122
AN - SCOPUS:85127147984
SN - 0165-0327
VL - 306
SP - 288
EP - 300
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -