Abstract
Auto reactive IL-2-producing T-cell hybridomas were established from New Zealand Black and White (B/W) F1 and MRL/1 mice. In B/WF1 mice the frequency of IL-2-producing hybridomas increased with age. It is necessary for the cells to recognize autologous MHC molecules in order to release IL-2. Inoculation of hybridoma cells into several mouse strains via the footpad produced significant swelling responses in an H-2-restricted manner. Finally, several autoimmune abnormalities were induced in naive H-2-compatible mice by i.v. inoculation of certain hybridoma cells. These results demonstrate that self-MHC molecule recognition by T cells plays an important role in the development of autoimmunity.
Original language | English (US) |
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Pages (from-to) | 113-119 |
Number of pages | 7 |
Journal | Immunology |
Volume | 64 |
Issue number | 1 |
State | Published - 1988 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology