The role of AP-1 in matrix metalloproteinase gene expression

C. W. Lin, H. I. Georgescu, C. H. Evans

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In an effort to understand the mechanism of matrix metalloproteinase (MMP) induction, lapine synoviocytes were isolated and incubated with phorbol myristate acetate (PMA) and autocrine "cell-activating factors" (CAF), agents which significantly increase MMP mRNA abundance. AP-1 complexes, formed by c-fos and c-jun which bind to 5′ residues of the MMP genes, seem causally related to MMP gene expression in response to PMA. However, although AP-1 DNA binding activity is strongly induced following exposure of synoviocytes to CAF, MMP gene expression in response to CAF does not correlate well with AP-1 activity and is not inhibited by antisense DNA to fos and jun. We hypothesize that there is a CAF-response factor involved in MMP gene expression and that this factor competes with the binding of the AP-1 complex to its target response element.

Original languageEnglish (US)
Pages (from-to)C215-C218
JournalAgents and Actions
Volume39
Issue number1 Supplement
DOIs
StatePublished - Mar 1 1993

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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