The role of antiplatelet therapy in aneurysm coiling

Rudy J. Rahme, Samer G. Zammar, Tarek Y.El Ahmadieh, Najib E.El Tecle, Sameer A. Ansari, Bernard R. Bendok

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Neurointerventional surgery offers the potential to deliver remarkable intravascular therapies for various neurovascular diseases and stroke. This approach, however, carries a risk of complications that need to be kept to a minimum. Thromboembolism is one of the most consequential complications of neurointerventional surgery in the treatment of intracranial aneurysms. Both antiplatelet and anticoagulant therapies have shown to reduce the risk of thromboembolism in this setting. In this paper, we review the role of antiplatelet therapy in the endovascular management of intracranial aneurysms. For unruptured aneurysms, the use of antiplatelet agents to pre-medicate patients before and during the procedure appears safe and effective in reducing the thrombotic risk. Abciximab has not been extensively studied, but seems to be safe as a salvage maneuver in the case of thrombus formation even in ruptured aneurysms (when the dome is relatively secure) with low rates of intraprocedure and procedure hemorrhagic complications. Further innovation and research are needed to further reduce thromboembolic risks of aneurysm coiling.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalNeurological research
Volume36
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Abciximab
  • Aneurysm
  • Antiplatelet therapy
  • Aspirin
  • Clopidogrel
  • Coiling
  • Complication
  • Thromboembolism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Rahme, R. J., Zammar, S. G., Ahmadieh, T. Y. E., Tecle, N. E. E., Ansari, S. A., & Bendok, B. R. (2014). The role of antiplatelet therapy in aneurysm coiling. Neurological research, 36(4), 383-388. https://doi.org/10.1179/1743132814Y.0000000317