The Role of Androgens and Estrogens in the Male Skeleton

Sundeep Khosla, John P. Bilezikian

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Past several years have witnessed a dramatic shift in the understanding of sex steroid regulation of the male skeleton. Androgens are clearly important for bone metabolism in males; what has been unexpected is the major role played by estrogen (E). With respect to men, convincing new evidence from multiple lines of investigation shows clearly that E is an important, if not the dominant sex steroid in regulating male bone metabolism. Although age-related bone loss in men had generally been assumed to be independent of sex steroids, it appears that the observed decreases in circulating bioavailable E and testosterone (T) levels may well be contributing to the development of involutional osteoporosis in men. These findings also suggest the possibility that other disorders associated with aging in men, such as cardiovascular disease, dementia, and prostate cancer, may also be related to these changes in sex steroid and in particular E levels.

Original languageEnglish (US)
Title of host publicationPrinciples of Gender-Specific Medicine
PublisherElsevier Inc.
Pages1021-1032
Number of pages12
Volume2
ISBN (Print)9780124409057
DOIs
StatePublished - 2004

Fingerprint

Skeleton
Androgens
Estrogens
Steroids
Bone
Metabolism
Osteoporosis
Bone and Bones
Dementia
Testosterone
Prostatic Neoplasms
Cardiovascular Diseases
Aging of materials

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Khosla, S., & Bilezikian, J. P. (2004). The Role of Androgens and Estrogens in the Male Skeleton. In Principles of Gender-Specific Medicine (Vol. 2, pp. 1021-1032). Elsevier Inc.. https://doi.org/10.1016/B978-012440905-7/50368-6

The Role of Androgens and Estrogens in the Male Skeleton. / Khosla, Sundeep; Bilezikian, John P.

Principles of Gender-Specific Medicine. Vol. 2 Elsevier Inc., 2004. p. 1021-1032.

Research output: Chapter in Book/Report/Conference proceedingChapter

Khosla, S & Bilezikian, JP 2004, The Role of Androgens and Estrogens in the Male Skeleton. in Principles of Gender-Specific Medicine. vol. 2, Elsevier Inc., pp. 1021-1032. https://doi.org/10.1016/B978-012440905-7/50368-6
Khosla S, Bilezikian JP. The Role of Androgens and Estrogens in the Male Skeleton. In Principles of Gender-Specific Medicine. Vol. 2. Elsevier Inc. 2004. p. 1021-1032 https://doi.org/10.1016/B978-012440905-7/50368-6
Khosla, Sundeep ; Bilezikian, John P. / The Role of Androgens and Estrogens in the Male Skeleton. Principles of Gender-Specific Medicine. Vol. 2 Elsevier Inc., 2004. pp. 1021-1032
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