The role of androgen receptor-regulated genes in prostate cancer progression

J. Lu, D. J. Tindall

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Androgen receptor (AR) plays an important role in the development and function of the normal prostate gland, as well as in prostate cancer progression. Androgen regulated gene expression is modulated by transcriptional activity of AR. Androgen deprivation therapy, which blocks the androgen-dependent activity of AR, usually relieves symptoms of advanced prostate cancer. However, the cancer eventually progresses to castration resistant prostate cancer (CRPC), where AR remains active, even at castrate-levels of androgen. Identification of direct AR-regulated gene will help us to understand the global aspects of AR signaling and the roles of AR target genes in prostate cancer. Direct AR regulated genes have been identified through integrated analysis of AR binding sites by ChIP-chip or ChIP-seq techniques and gene expression profiles. Here we will review the genome-wide AR binding sites in target genes and their roles in prostate cancer progression.

Original languageEnglish (US)
Title of host publicationAndrogen Receptor
Subtitle of host publicationStructural Biology, Genetics and Molecular Defects
PublisherNova Science Publishers, Inc.
Pages107-128
Number of pages22
ISBN (Electronic)9781629487175
ISBN (Print)9781629486932
StatePublished - Jan 1 2014

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Keywords

  • Androgen receptor
  • Androgen receptor regulated genes
  • ChIP-chip
  • ChIP-seq
  • Prostate cancer

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Lu, J., & Tindall, D. J. (2014). The role of androgen receptor-regulated genes in prostate cancer progression. In Androgen Receptor: Structural Biology, Genetics and Molecular Defects (pp. 107-128). Nova Science Publishers, Inc..