The Rochester Diabetic Neuropathy Study: Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests

Peter J Dyck, K. M. Kratz, K. A. Lehman, J. L. Karnes, L. J. Melton, P. C. O'Brien, William J Litchy, Anthony John Windebank, B. E. Smith, Phillip Anson Low, F. J. Service, R. A. Rizza, B. R. Zimmerman

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN-The Rochester Diabetic Neuropathy Study (RDNS) - is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same population, serve as controls. For patients 10 to 70 years old, the RDNS cohort is representative of diabetics living in Rochester, MN. We assessed reproducibility of tests used to characterize and quantitate severity of neuropathy in 20 diabetic subjects without neuropathy and with varying severities of neuropathy. Using intraclass correlation coefficient (rI) as a measure of test reproducibility, we found high rI (usually 0.9 or better) with small confidence intervals for the Neurologic Disability Score (NDS); weakness subset of NDS (W-NDS); vibratory and cooling detection thresholds (using computer-assisted sensory examination [CASE] IV); compound muscle action potentials; sensory nerve action potentials; and motor nerve conduction velocities. There was good agreement among three trained observors for NDS and the W-NDS.

Original languageEnglish (US)
Pages (from-to)799-807
Number of pages9
JournalNeurology
Volume41
Issue number6
StatePublished - Jun 1991

Fingerprint

Diabetic Neuropathies
Selection Bias
Nervous System
Action Potentials
Neural Conduction
Population
Longitudinal Studies
Cohort Studies
Cross-Sectional Studies
Confidence Intervals
Muscles

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dyck, P. J., Kratz, K. M., Lehman, K. A., Karnes, J. L., Melton, L. J., O'Brien, P. C., ... Zimmerman, B. R. (1991). The Rochester Diabetic Neuropathy Study: Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests. Neurology, 41(6), 799-807.

The Rochester Diabetic Neuropathy Study : Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests. / Dyck, Peter J; Kratz, K. M.; Lehman, K. A.; Karnes, J. L.; Melton, L. J.; O'Brien, P. C.; Litchy, William J; Windebank, Anthony John; Smith, B. E.; Low, Phillip Anson; Service, F. J.; Rizza, R. A.; Zimmerman, B. R.

In: Neurology, Vol. 41, No. 6, 06.1991, p. 799-807.

Research output: Contribution to journalArticle

Dyck, PJ, Kratz, KM, Lehman, KA, Karnes, JL, Melton, LJ, O'Brien, PC, Litchy, WJ, Windebank, AJ, Smith, BE, Low, PA, Service, FJ, Rizza, RA & Zimmerman, BR 1991, 'The Rochester Diabetic Neuropathy Study: Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests', Neurology, vol. 41, no. 6, pp. 799-807.
Dyck, Peter J ; Kratz, K. M. ; Lehman, K. A. ; Karnes, J. L. ; Melton, L. J. ; O'Brien, P. C. ; Litchy, William J ; Windebank, Anthony John ; Smith, B. E. ; Low, Phillip Anson ; Service, F. J. ; Rizza, R. A. ; Zimmerman, B. R. / The Rochester Diabetic Neuropathy Study : Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests. In: Neurology. 1991 ; Vol. 41, No. 6. pp. 799-807.
@article{8879acc4bc85442cb164693e0fa3be15,
title = "The Rochester Diabetic Neuropathy Study: Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests",
abstract = "A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN-The Rochester Diabetic Neuropathy Study (RDNS) - is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same population, serve as controls. For patients 10 to 70 years old, the RDNS cohort is representative of diabetics living in Rochester, MN. We assessed reproducibility of tests used to characterize and quantitate severity of neuropathy in 20 diabetic subjects without neuropathy and with varying severities of neuropathy. Using intraclass correlation coefficient (rI) as a measure of test reproducibility, we found high rI (usually 0.9 or better) with small confidence intervals for the Neurologic Disability Score (NDS); weakness subset of NDS (W-NDS); vibratory and cooling detection thresholds (using computer-assisted sensory examination [CASE] IV); compound muscle action potentials; sensory nerve action potentials; and motor nerve conduction velocities. There was good agreement among three trained observors for NDS and the W-NDS.",
author = "Dyck, {Peter J} and Kratz, {K. M.} and Lehman, {K. A.} and Karnes, {J. L.} and Melton, {L. J.} and O'Brien, {P. C.} and Litchy, {William J} and Windebank, {Anthony John} and Smith, {B. E.} and Low, {Phillip Anson} and Service, {F. J.} and Rizza, {R. A.} and Zimmerman, {B. R.}",
year = "1991",
month = "6",
language = "English (US)",
volume = "41",
pages = "799--807",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - The Rochester Diabetic Neuropathy Study

T2 - Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests

AU - Dyck, Peter J

AU - Kratz, K. M.

AU - Lehman, K. A.

AU - Karnes, J. L.

AU - Melton, L. J.

AU - O'Brien, P. C.

AU - Litchy, William J

AU - Windebank, Anthony John

AU - Smith, B. E.

AU - Low, Phillip Anson

AU - Service, F. J.

AU - Rizza, R. A.

AU - Zimmerman, B. R.

PY - 1991/6

Y1 - 1991/6

N2 - A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN-The Rochester Diabetic Neuropathy Study (RDNS) - is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same population, serve as controls. For patients 10 to 70 years old, the RDNS cohort is representative of diabetics living in Rochester, MN. We assessed reproducibility of tests used to characterize and quantitate severity of neuropathy in 20 diabetic subjects without neuropathy and with varying severities of neuropathy. Using intraclass correlation coefficient (rI) as a measure of test reproducibility, we found high rI (usually 0.9 or better) with small confidence intervals for the Neurologic Disability Score (NDS); weakness subset of NDS (W-NDS); vibratory and cooling detection thresholds (using computer-assisted sensory examination [CASE] IV); compound muscle action potentials; sensory nerve action potentials; and motor nerve conduction velocities. There was good agreement among three trained observors for NDS and the W-NDS.

AB - A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN-The Rochester Diabetic Neuropathy Study (RDNS) - is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same population, serve as controls. For patients 10 to 70 years old, the RDNS cohort is representative of diabetics living in Rochester, MN. We assessed reproducibility of tests used to characterize and quantitate severity of neuropathy in 20 diabetic subjects without neuropathy and with varying severities of neuropathy. Using intraclass correlation coefficient (rI) as a measure of test reproducibility, we found high rI (usually 0.9 or better) with small confidence intervals for the Neurologic Disability Score (NDS); weakness subset of NDS (W-NDS); vibratory and cooling detection thresholds (using computer-assisted sensory examination [CASE] IV); compound muscle action potentials; sensory nerve action potentials; and motor nerve conduction velocities. There was good agreement among three trained observors for NDS and the W-NDS.

UR - http://www.scopus.com/inward/record.url?scp=0025764532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025764532&partnerID=8YFLogxK

M3 - Article

C2 - 2046920

AN - SCOPUS:0025764532

VL - 41

SP - 799

EP - 807

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -