The risk of prostate cancer in pilots: a meta-analysis

David Raslau, Douglas T. Summerfield, Abd Moain Abu Dabrh, Lawrence W. Steinkraus, Mohammad H Murad

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND: Aviation exposes pilots to various occupationally related hazards, including ionizing radiation and chemical combustion. The possible increased risk of prostate cancer among pilots in comparison to the general population is a subject of debate. This systematic review and meta-analysis aimed to determine the quality of supporting evidence and magnitude of this association.

METHODS: All studies pertaining to prostate cancer in pilots were retrieved from multiple databases and from a manual search. Any study that assessed the incidence of prostate cancer relative to the incidence in the general population was included regardless of language or size. A random effect model was used to pool relative risks (RR) across studies. Heterogeneity was assessed using the Q statistic and I².

RESULTS: Eight studies with a low risk of bias were included in the meta-analysis. Pilots had an increased risk of developing prostate cancer compared to the general population [RR 2.0; 95% confidence interval (CI), 1.5-2.7]. The analysis was associated with substantial heterogeneity (I² = 79%). Several subgroups had significantly increased risk, such as African American pilots (RR 10.00; 95% CI, 5.04-19.86) and military pilots (RR 3.30; 95% CI, 2.03-5.39).

CONCLUSION: Pilots are at least twice as likely to develop prostate cancer compared to the general population. The implications of these findings are important considering the high prevalence of prostate cancer and the large number of pilots in the workforce.

Original languageEnglish (US)
Pages (from-to)112-117
Number of pages6
JournalAerospace medicine and human performance
Volume86
Issue number2
DOIs
StatePublished - Feb 1 2015

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Meta-Analysis
Prostatic Neoplasms
Confidence Intervals
Population
Aviation
Pilots
Ionizing Radiation
African Americans
Cohort Studies
Language
Databases
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The risk of prostate cancer in pilots : a meta-analysis. / Raslau, David; Summerfield, Douglas T.; Abu Dabrh, Abd Moain; Steinkraus, Lawrence W.; Murad, Mohammad H.

In: Aerospace medicine and human performance, Vol. 86, No. 2, 01.02.2015, p. 112-117.

Research output: Contribution to journalArticle

Raslau, David ; Summerfield, Douglas T. ; Abu Dabrh, Abd Moain ; Steinkraus, Lawrence W. ; Murad, Mohammad H. / The risk of prostate cancer in pilots : a meta-analysis. In: Aerospace medicine and human performance. 2015 ; Vol. 86, No. 2. pp. 112-117.
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