The rise and fall of the craniocervical junction relative to the hard palate: a lifetime story

Grant W. Mallory, Grigoriy Arutyunyan, Meghan E. Murphy, Kathryn M. Van Abel, Elvis Francois, Nicholas M. Wetjen, Jeremy L. Fogelson, Erin K. O'Brien, Michelle J. Clarke, Laurence J. Eckel, Jamie Van Gompel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECT: Endoscopic approaches to the anterior craniocervical junction are increasing in frequency. Choice of oral versus endoscopic endonasal approach to the odontoid often depends on the relationship of the C1-2 complex to the hard palate. However, it is not known how this relevant anatomy changes with age. We hypothesize that there is a dynamic relationship of C-2 and the hard palate, which changes with age, and potentially affects the choice of surgical approach. The aim of this study was to characterize the relationship of C-2 relative to the hard palate with respect to age and sex.

METHODS: Emergency department billing and trauma records from 2008 to 2014 were reviewed for patients of all ages who underwent cervical or maxillofacial CT as part of a trauma evaluation for closed head injury. Patients who had a CT scan that allowed adequate visualization of the hard palate, opisthion, and upper cervical spine (C-1 and C-2) were included. Patients who had cervical or displaced facial/skull base fractures, a history of rheumatoid arthritis, or craniofacial anomalies were excluded. The distance from McGregor's palatooccipital line to the midpoint of the inferior endplate of C-2 (McL-C2) was measured on midsagittal CT scans. Patients were grouped by decile of age and by sex. A 1-way ANOVA was performed with each respective grouping.

RESULTS: Ultimately, 483 patients (29% female) were included. The mean age was 46 ± 24 years. The majority of patients studied were in the 2nd through 8th decades of life (85%). Significant variation was found between McL-C2 and decile of age (p < 0.001) and sex (p < 0.001). The mean McL-C2 was 27 mm in the 1st decade of life compared with the population mean of 37 mm. The mean McL-C2 was also noted to be smaller in females (mean difference 4.8 mm, p < 0.0001). Both decile of age (p = 0.0009) and sex (p < 0.0001) were independently correlated with McL-C2 on multivariate analysis.

CONCLUSIONS: The relationship of C-2 and the hard palate significantly varies with respect to age and sex, descending relative to the hard palate a full centimeter on average in adulthood. These findings may have relevance in determining optimal surgical approaches for addressing pathology involving the anterior craniocervical junction.

Original languageEnglish (US)
Pages (from-to)521-526
Number of pages6
JournalJournal of neurosurgery. Spine
Volume24
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Hard Palate
Skull Fractures
Closed Head Injuries
Skull Base
Wounds and Injuries
Hospital Emergency Service
Rheumatoid Arthritis
Anatomy
Analysis of Variance
Spine
Multivariate Analysis
Pathology
Population

Keywords

  • anatomy
  • C-1
  • C-2
  • cervical
  • cervicomedullary junction
  • craniocervical
  • EN = endoscopic transnasal
  • endoscopic approaches
  • EO = endoscopic transoral;
  • McL–C2 = distance from McGregor's palatooccipital line to the midpoint of the inferior endplate of C-2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The rise and fall of the craniocervical junction relative to the hard palate : a lifetime story. / Mallory, Grant W.; Arutyunyan, Grigoriy; Murphy, Meghan E.; Van Abel, Kathryn M.; Francois, Elvis; Wetjen, Nicholas M.; Fogelson, Jeremy L.; O'Brien, Erin K.; Clarke, Michelle J.; Eckel, Laurence J.; Van Gompel, Jamie.

In: Journal of neurosurgery. Spine, Vol. 24, No. 4, 01.04.2016, p. 521-526.

Research output: Contribution to journalArticle

Mallory, GW, Arutyunyan, G, Murphy, ME, Van Abel, KM, Francois, E, Wetjen, NM, Fogelson, JL, O'Brien, EK, Clarke, MJ, Eckel, LJ & Van Gompel, J 2016, 'The rise and fall of the craniocervical junction relative to the hard palate: a lifetime story', Journal of neurosurgery. Spine, vol. 24, no. 4, pp. 521-526. https://doi.org/10.3171/2015.6.SPINE141250
Mallory, Grant W. ; Arutyunyan, Grigoriy ; Murphy, Meghan E. ; Van Abel, Kathryn M. ; Francois, Elvis ; Wetjen, Nicholas M. ; Fogelson, Jeremy L. ; O'Brien, Erin K. ; Clarke, Michelle J. ; Eckel, Laurence J. ; Van Gompel, Jamie. / The rise and fall of the craniocervical junction relative to the hard palate : a lifetime story. In: Journal of neurosurgery. Spine. 2016 ; Vol. 24, No. 4. pp. 521-526.
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abstract = "OBJECT: Endoscopic approaches to the anterior craniocervical junction are increasing in frequency. Choice of oral versus endoscopic endonasal approach to the odontoid often depends on the relationship of the C1-2 complex to the hard palate. However, it is not known how this relevant anatomy changes with age. We hypothesize that there is a dynamic relationship of C-2 and the hard palate, which changes with age, and potentially affects the choice of surgical approach. The aim of this study was to characterize the relationship of C-2 relative to the hard palate with respect to age and sex.METHODS: Emergency department billing and trauma records from 2008 to 2014 were reviewed for patients of all ages who underwent cervical or maxillofacial CT as part of a trauma evaluation for closed head injury. Patients who had a CT scan that allowed adequate visualization of the hard palate, opisthion, and upper cervical spine (C-1 and C-2) were included. Patients who had cervical or displaced facial/skull base fractures, a history of rheumatoid arthritis, or craniofacial anomalies were excluded. The distance from McGregor's palatooccipital line to the midpoint of the inferior endplate of C-2 (McL-C2) was measured on midsagittal CT scans. Patients were grouped by decile of age and by sex. A 1-way ANOVA was performed with each respective grouping.RESULTS: Ultimately, 483 patients (29{\%} female) were included. The mean age was 46 ± 24 years. The majority of patients studied were in the 2nd through 8th decades of life (85{\%}). Significant variation was found between McL-C2 and decile of age (p < 0.001) and sex (p < 0.001). The mean McL-C2 was 27 mm in the 1st decade of life compared with the population mean of 37 mm. The mean McL-C2 was also noted to be smaller in females (mean difference 4.8 mm, p < 0.0001). Both decile of age (p = 0.0009) and sex (p < 0.0001) were independently correlated with McL-C2 on multivariate analysis.CONCLUSIONS: The relationship of C-2 and the hard palate significantly varies with respect to age and sex, descending relative to the hard palate a full centimeter on average in adulthood. These findings may have relevance in determining optimal surgical approaches for addressing pathology involving the anterior craniocervical junction.",
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T2 - a lifetime story

AU - Mallory, Grant W.

AU - Arutyunyan, Grigoriy

AU - Murphy, Meghan E.

AU - Van Abel, Kathryn M.

AU - Francois, Elvis

AU - Wetjen, Nicholas M.

AU - Fogelson, Jeremy L.

AU - O'Brien, Erin K.

AU - Clarke, Michelle J.

AU - Eckel, Laurence J.

AU - Van Gompel, Jamie

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N2 - OBJECT: Endoscopic approaches to the anterior craniocervical junction are increasing in frequency. Choice of oral versus endoscopic endonasal approach to the odontoid often depends on the relationship of the C1-2 complex to the hard palate. However, it is not known how this relevant anatomy changes with age. We hypothesize that there is a dynamic relationship of C-2 and the hard palate, which changes with age, and potentially affects the choice of surgical approach. The aim of this study was to characterize the relationship of C-2 relative to the hard palate with respect to age and sex.METHODS: Emergency department billing and trauma records from 2008 to 2014 were reviewed for patients of all ages who underwent cervical or maxillofacial CT as part of a trauma evaluation for closed head injury. Patients who had a CT scan that allowed adequate visualization of the hard palate, opisthion, and upper cervical spine (C-1 and C-2) were included. Patients who had cervical or displaced facial/skull base fractures, a history of rheumatoid arthritis, or craniofacial anomalies were excluded. The distance from McGregor's palatooccipital line to the midpoint of the inferior endplate of C-2 (McL-C2) was measured on midsagittal CT scans. Patients were grouped by decile of age and by sex. A 1-way ANOVA was performed with each respective grouping.RESULTS: Ultimately, 483 patients (29% female) were included. The mean age was 46 ± 24 years. The majority of patients studied were in the 2nd through 8th decades of life (85%). Significant variation was found between McL-C2 and decile of age (p < 0.001) and sex (p < 0.001). The mean McL-C2 was 27 mm in the 1st decade of life compared with the population mean of 37 mm. The mean McL-C2 was also noted to be smaller in females (mean difference 4.8 mm, p < 0.0001). Both decile of age (p = 0.0009) and sex (p < 0.0001) were independently correlated with McL-C2 on multivariate analysis.CONCLUSIONS: The relationship of C-2 and the hard palate significantly varies with respect to age and sex, descending relative to the hard palate a full centimeter on average in adulthood. These findings may have relevance in determining optimal surgical approaches for addressing pathology involving the anterior craniocervical junction.

AB - OBJECT: Endoscopic approaches to the anterior craniocervical junction are increasing in frequency. Choice of oral versus endoscopic endonasal approach to the odontoid often depends on the relationship of the C1-2 complex to the hard palate. However, it is not known how this relevant anatomy changes with age. We hypothesize that there is a dynamic relationship of C-2 and the hard palate, which changes with age, and potentially affects the choice of surgical approach. The aim of this study was to characterize the relationship of C-2 relative to the hard palate with respect to age and sex.METHODS: Emergency department billing and trauma records from 2008 to 2014 were reviewed for patients of all ages who underwent cervical or maxillofacial CT as part of a trauma evaluation for closed head injury. Patients who had a CT scan that allowed adequate visualization of the hard palate, opisthion, and upper cervical spine (C-1 and C-2) were included. Patients who had cervical or displaced facial/skull base fractures, a history of rheumatoid arthritis, or craniofacial anomalies were excluded. The distance from McGregor's palatooccipital line to the midpoint of the inferior endplate of C-2 (McL-C2) was measured on midsagittal CT scans. Patients were grouped by decile of age and by sex. A 1-way ANOVA was performed with each respective grouping.RESULTS: Ultimately, 483 patients (29% female) were included. The mean age was 46 ± 24 years. The majority of patients studied were in the 2nd through 8th decades of life (85%). Significant variation was found between McL-C2 and decile of age (p < 0.001) and sex (p < 0.001). The mean McL-C2 was 27 mm in the 1st decade of life compared with the population mean of 37 mm. The mean McL-C2 was also noted to be smaller in females (mean difference 4.8 mm, p < 0.0001). Both decile of age (p = 0.0009) and sex (p < 0.0001) were independently correlated with McL-C2 on multivariate analysis.CONCLUSIONS: The relationship of C-2 and the hard palate significantly varies with respect to age and sex, descending relative to the hard palate a full centimeter on average in adulthood. These findings may have relevance in determining optimal surgical approaches for addressing pathology involving the anterior craniocervical junction.

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KW - EN = endoscopic transnasal

KW - endoscopic approaches

KW - EO = endoscopic transoral;

KW - McL–C2 = distance from McGregor's palatooccipital line to the midpoint of the inferior endplate of C-2

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