The relevance of lymphoid cell migration to immunodeficiency syndromes

J. B. Hay, N. J. Abernethy, A. N. Kalaaji, G. F. Teare, P. Borron

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It has been known for some time that antigen stimulation can alter lymphocyte traffic patterns and that viruses are particularly potent in this respect; such alterations may be a consequence of host-derived factors. The retention of lymphocytes in lymph nodes can be sustained for several hours with locally administered interferon (IFN)α. The extravasation of lymphocytes from blood into non-lymphoid tissues can be induced in the skin with IFNγ and particularly tumor necrosis factor (TNF)α. Recent evidence supports the concept that the migratory capacity of CD4 + cells differs from the capacity of CD8 + cells. Agents (cytokines?) which differentially affect the traffic of these two sub-sets have not yet been described but such a possibility has not been adequately tested. Several new molecules have been defined which alter the interactions between lymphoctyes and blood vascular endothelial cells, and these may be important in the critical adhesive event in lymphocyte traffic. In both rat and sheep, it has been possible to cultivate post-capillary endothelial cells from lymphoid tissue, and this may be a helpful approach to studying the mechanisms and molecules involved in adhesion. New cell tracking dyes recently available (Zynaxis Cell Science) permit more significant, longterm studies on the life span of lymphocyte sub-sets and their migratory status. In our experiments, labeled lymphocytes can be followed in vivo for over 30 days. Traffic alterations may explain some of the abnormalities in immunodeficiency states.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalLymphology
Volume23
Issue number2
StatePublished - 1990
Externally publishedYes

Fingerprint

Cell Movement
Lymphocytes
Interferons
Endothelial Cells
Cell Tracking
Lymphoid Tissue
Adhesives
Sheep
Coloring Agents
Tumor Necrosis Factor-alpha
Lymph Nodes
Cytokines
Viruses
Antigens
Skin

ASJC Scopus subject areas

  • Immunology

Cite this

Hay, J. B., Abernethy, N. J., Kalaaji, A. N., Teare, G. F., & Borron, P. (1990). The relevance of lymphoid cell migration to immunodeficiency syndromes. Lymphology, 23(2), 64-72.

The relevance of lymphoid cell migration to immunodeficiency syndromes. / Hay, J. B.; Abernethy, N. J.; Kalaaji, A. N.; Teare, G. F.; Borron, P.

In: Lymphology, Vol. 23, No. 2, 1990, p. 64-72.

Research output: Contribution to journalArticle

Hay, JB, Abernethy, NJ, Kalaaji, AN, Teare, GF & Borron, P 1990, 'The relevance of lymphoid cell migration to immunodeficiency syndromes', Lymphology, vol. 23, no. 2, pp. 64-72.
Hay JB, Abernethy NJ, Kalaaji AN, Teare GF, Borron P. The relevance of lymphoid cell migration to immunodeficiency syndromes. Lymphology. 1990;23(2):64-72.
Hay, J. B. ; Abernethy, N. J. ; Kalaaji, A. N. ; Teare, G. F. ; Borron, P. / The relevance of lymphoid cell migration to immunodeficiency syndromes. In: Lymphology. 1990 ; Vol. 23, No. 2. pp. 64-72.
@article{c5c9defeb1384be6a9c6a62586400d3f,
title = "The relevance of lymphoid cell migration to immunodeficiency syndromes",
abstract = "It has been known for some time that antigen stimulation can alter lymphocyte traffic patterns and that viruses are particularly potent in this respect; such alterations may be a consequence of host-derived factors. The retention of lymphocytes in lymph nodes can be sustained for several hours with locally administered interferon (IFN)α. The extravasation of lymphocytes from blood into non-lymphoid tissues can be induced in the skin with IFNγ and particularly tumor necrosis factor (TNF)α. Recent evidence supports the concept that the migratory capacity of CD4 + cells differs from the capacity of CD8 + cells. Agents (cytokines?) which differentially affect the traffic of these two sub-sets have not yet been described but such a possibility has not been adequately tested. Several new molecules have been defined which alter the interactions between lymphoctyes and blood vascular endothelial cells, and these may be important in the critical adhesive event in lymphocyte traffic. In both rat and sheep, it has been possible to cultivate post-capillary endothelial cells from lymphoid tissue, and this may be a helpful approach to studying the mechanisms and molecules involved in adhesion. New cell tracking dyes recently available (Zynaxis Cell Science) permit more significant, longterm studies on the life span of lymphocyte sub-sets and their migratory status. In our experiments, labeled lymphocytes can be followed in vivo for over 30 days. Traffic alterations may explain some of the abnormalities in immunodeficiency states.",
author = "Hay, {J. B.} and Abernethy, {N. J.} and Kalaaji, {A. N.} and Teare, {G. F.} and P. Borron",
year = "1990",
language = "English (US)",
volume = "23",
pages = "64--72",
journal = "Lymphology",
issn = "0024-7766",
publisher = "International Society of Lymphology",
number = "2",

}

TY - JOUR

T1 - The relevance of lymphoid cell migration to immunodeficiency syndromes

AU - Hay, J. B.

AU - Abernethy, N. J.

AU - Kalaaji, A. N.

AU - Teare, G. F.

AU - Borron, P.

PY - 1990

Y1 - 1990

N2 - It has been known for some time that antigen stimulation can alter lymphocyte traffic patterns and that viruses are particularly potent in this respect; such alterations may be a consequence of host-derived factors. The retention of lymphocytes in lymph nodes can be sustained for several hours with locally administered interferon (IFN)α. The extravasation of lymphocytes from blood into non-lymphoid tissues can be induced in the skin with IFNγ and particularly tumor necrosis factor (TNF)α. Recent evidence supports the concept that the migratory capacity of CD4 + cells differs from the capacity of CD8 + cells. Agents (cytokines?) which differentially affect the traffic of these two sub-sets have not yet been described but such a possibility has not been adequately tested. Several new molecules have been defined which alter the interactions between lymphoctyes and blood vascular endothelial cells, and these may be important in the critical adhesive event in lymphocyte traffic. In both rat and sheep, it has been possible to cultivate post-capillary endothelial cells from lymphoid tissue, and this may be a helpful approach to studying the mechanisms and molecules involved in adhesion. New cell tracking dyes recently available (Zynaxis Cell Science) permit more significant, longterm studies on the life span of lymphocyte sub-sets and their migratory status. In our experiments, labeled lymphocytes can be followed in vivo for over 30 days. Traffic alterations may explain some of the abnormalities in immunodeficiency states.

AB - It has been known for some time that antigen stimulation can alter lymphocyte traffic patterns and that viruses are particularly potent in this respect; such alterations may be a consequence of host-derived factors. The retention of lymphocytes in lymph nodes can be sustained for several hours with locally administered interferon (IFN)α. The extravasation of lymphocytes from blood into non-lymphoid tissues can be induced in the skin with IFNγ and particularly tumor necrosis factor (TNF)α. Recent evidence supports the concept that the migratory capacity of CD4 + cells differs from the capacity of CD8 + cells. Agents (cytokines?) which differentially affect the traffic of these two sub-sets have not yet been described but such a possibility has not been adequately tested. Several new molecules have been defined which alter the interactions between lymphoctyes and blood vascular endothelial cells, and these may be important in the critical adhesive event in lymphocyte traffic. In both rat and sheep, it has been possible to cultivate post-capillary endothelial cells from lymphoid tissue, and this may be a helpful approach to studying the mechanisms and molecules involved in adhesion. New cell tracking dyes recently available (Zynaxis Cell Science) permit more significant, longterm studies on the life span of lymphocyte sub-sets and their migratory status. In our experiments, labeled lymphocytes can be followed in vivo for over 30 days. Traffic alterations may explain some of the abnormalities in immunodeficiency states.

UR - http://www.scopus.com/inward/record.url?scp=0025030633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025030633&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 64

EP - 72

JO - Lymphology

JF - Lymphology

SN - 0024-7766

IS - 2

ER -