The Relationship Between Serum Neuron-Specific Enolase Levels and Severity of Bleeding and Functional Outcomes in Patients With Nontraumatic Subarachnoid Hemorrhage

Rabih G. Tawk, Sanjeet S. Grewal, Michael G. Heckman, Bhupendra Rawal, David A. Miller, Drucilla Edmonston, Jennifer L. Ferguson, Ramon Navarro, Lauren Ng, Benjamin L. Brown, James F Meschia, William D. Freeman

Research output: Contribution to journalArticle

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Abstract

BACKGROUND:: The value of neuron-specific enolase (NSE) in predicting clinical outcomes has been investigated in a variety of neurological disorders. OBJECTIVE:: To investigate the associations of serum NSE with severity of bleeding and functional outcomes in patients with subarachnoid hemorrhage (SAH). METHODS:: We retrospectively reviewed the records of patients with SAH from June 2008 to June 2012. The severity of SAH bleeding at admission was measured radiographically with the Fisher scale and clinically with the Glasgow Coma Scale, Hunt and Hess grade, and World Federation of Neurologic Surgeons scale. Outcomes were assessed with the modified Rankin Scale at discharge. RESULTS:: We identified 309 patients with nontraumatic SAH, and 71 had NSE testing. Median age was 54 years (range, 23-87 years), and 44% were male. In multivariable analysis, increased NSE was associated with a poorer Hunt and Hess grade (P = .003), World Federation of Neurologic Surgeons scale score (P <.001), and Glasgow Coma Scale score (P = .003) and worse outcomes (modified Rankin Scale at discharge; P = .001). There was no significant association between NSE level and Fisher grade (P = .81) in multivariable analysis. CONCLUSION:: We found a significant association between higher NSE levels and poorer clinical presentations and worse outcomes. Although it is still early for any relevant clinical conclusions, our results suggest that NSE holds promise as a tool for screening patients at increased risk of poor outcomes after SAH. ABBREVIATIONS:: BMI, body mass indexGCS, Glasgow Coma ScalemRS, modified Rankin ScaleNSE, neuron-specific enolaseSAH, subarachnoid hemorrhageWFNS, World Federation of Neurologic Surgeons

Original languageEnglish (US)
JournalNeurosurgery
DOIs
StateAccepted/In press - Nov 24 2015

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Phosphopyruvate Hydratase
Subarachnoid Hemorrhage
Hemorrhage
Serum
Nervous System
Glasgow Coma Scale
Coma
Nervous System Diseases
Neurons
Surgeons

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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The Relationship Between Serum Neuron-Specific Enolase Levels and Severity of Bleeding and Functional Outcomes in Patients With Nontraumatic Subarachnoid Hemorrhage. / Tawk, Rabih G.; Grewal, Sanjeet S.; Heckman, Michael G.; Rawal, Bhupendra; Miller, David A.; Edmonston, Drucilla; Ferguson, Jennifer L.; Navarro, Ramon; Ng, Lauren; Brown, Benjamin L.; Meschia, James F; Freeman, William D.

In: Neurosurgery, 24.11.2015.

Research output: Contribution to journalArticle

Tawk, Rabih G. ; Grewal, Sanjeet S. ; Heckman, Michael G. ; Rawal, Bhupendra ; Miller, David A. ; Edmonston, Drucilla ; Ferguson, Jennifer L. ; Navarro, Ramon ; Ng, Lauren ; Brown, Benjamin L. ; Meschia, James F ; Freeman, William D. / The Relationship Between Serum Neuron-Specific Enolase Levels and Severity of Bleeding and Functional Outcomes in Patients With Nontraumatic Subarachnoid Hemorrhage. In: Neurosurgery. 2015.
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abstract = "BACKGROUND:: The value of neuron-specific enolase (NSE) in predicting clinical outcomes has been investigated in a variety of neurological disorders. OBJECTIVE:: To investigate the associations of serum NSE with severity of bleeding and functional outcomes in patients with subarachnoid hemorrhage (SAH). METHODS:: We retrospectively reviewed the records of patients with SAH from June 2008 to June 2012. The severity of SAH bleeding at admission was measured radiographically with the Fisher scale and clinically with the Glasgow Coma Scale, Hunt and Hess grade, and World Federation of Neurologic Surgeons scale. Outcomes were assessed with the modified Rankin Scale at discharge. RESULTS:: We identified 309 patients with nontraumatic SAH, and 71 had NSE testing. Median age was 54 years (range, 23-87 years), and 44{\%} were male. In multivariable analysis, increased NSE was associated with a poorer Hunt and Hess grade (P = .003), World Federation of Neurologic Surgeons scale score (P <.001), and Glasgow Coma Scale score (P = .003) and worse outcomes (modified Rankin Scale at discharge; P = .001). There was no significant association between NSE level and Fisher grade (P = .81) in multivariable analysis. CONCLUSION:: We found a significant association between higher NSE levels and poorer clinical presentations and worse outcomes. Although it is still early for any relevant clinical conclusions, our results suggest that NSE holds promise as a tool for screening patients at increased risk of poor outcomes after SAH. ABBREVIATIONS:: BMI, body mass indexGCS, Glasgow Coma ScalemRS, modified Rankin ScaleNSE, neuron-specific enolaseSAH, subarachnoid hemorrhageWFNS, World Federation of Neurologic Surgeons",
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AU - Tawk, Rabih G.

AU - Grewal, Sanjeet S.

AU - Heckman, Michael G.

AU - Rawal, Bhupendra

AU - Miller, David A.

AU - Edmonston, Drucilla

AU - Ferguson, Jennifer L.

AU - Navarro, Ramon

AU - Ng, Lauren

AU - Brown, Benjamin L.

AU - Meschia, James F

AU - Freeman, William D.

PY - 2015/11/24

Y1 - 2015/11/24

N2 - BACKGROUND:: The value of neuron-specific enolase (NSE) in predicting clinical outcomes has been investigated in a variety of neurological disorders. OBJECTIVE:: To investigate the associations of serum NSE with severity of bleeding and functional outcomes in patients with subarachnoid hemorrhage (SAH). METHODS:: We retrospectively reviewed the records of patients with SAH from June 2008 to June 2012. The severity of SAH bleeding at admission was measured radiographically with the Fisher scale and clinically with the Glasgow Coma Scale, Hunt and Hess grade, and World Federation of Neurologic Surgeons scale. Outcomes were assessed with the modified Rankin Scale at discharge. RESULTS:: We identified 309 patients with nontraumatic SAH, and 71 had NSE testing. Median age was 54 years (range, 23-87 years), and 44% were male. In multivariable analysis, increased NSE was associated with a poorer Hunt and Hess grade (P = .003), World Federation of Neurologic Surgeons scale score (P <.001), and Glasgow Coma Scale score (P = .003) and worse outcomes (modified Rankin Scale at discharge; P = .001). There was no significant association between NSE level and Fisher grade (P = .81) in multivariable analysis. CONCLUSION:: We found a significant association between higher NSE levels and poorer clinical presentations and worse outcomes. Although it is still early for any relevant clinical conclusions, our results suggest that NSE holds promise as a tool for screening patients at increased risk of poor outcomes after SAH. ABBREVIATIONS:: BMI, body mass indexGCS, Glasgow Coma ScalemRS, modified Rankin ScaleNSE, neuron-specific enolaseSAH, subarachnoid hemorrhageWFNS, World Federation of Neurologic Surgeons

AB - BACKGROUND:: The value of neuron-specific enolase (NSE) in predicting clinical outcomes has been investigated in a variety of neurological disorders. OBJECTIVE:: To investigate the associations of serum NSE with severity of bleeding and functional outcomes in patients with subarachnoid hemorrhage (SAH). METHODS:: We retrospectively reviewed the records of patients with SAH from June 2008 to June 2012. The severity of SAH bleeding at admission was measured radiographically with the Fisher scale and clinically with the Glasgow Coma Scale, Hunt and Hess grade, and World Federation of Neurologic Surgeons scale. Outcomes were assessed with the modified Rankin Scale at discharge. RESULTS:: We identified 309 patients with nontraumatic SAH, and 71 had NSE testing. Median age was 54 years (range, 23-87 years), and 44% were male. In multivariable analysis, increased NSE was associated with a poorer Hunt and Hess grade (P = .003), World Federation of Neurologic Surgeons scale score (P <.001), and Glasgow Coma Scale score (P = .003) and worse outcomes (modified Rankin Scale at discharge; P = .001). There was no significant association between NSE level and Fisher grade (P = .81) in multivariable analysis. CONCLUSION:: We found a significant association between higher NSE levels and poorer clinical presentations and worse outcomes. Although it is still early for any relevant clinical conclusions, our results suggest that NSE holds promise as a tool for screening patients at increased risk of poor outcomes after SAH. ABBREVIATIONS:: BMI, body mass indexGCS, Glasgow Coma ScalemRS, modified Rankin ScaleNSE, neuron-specific enolaseSAH, subarachnoid hemorrhageWFNS, World Federation of Neurologic Surgeons

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