The relationship between renal cortical volume and predisposition to hypertension

Allen L. Flickinger, Lilach O Lerman, Patrick F. Sheedy, Stephen T Turner

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It has been proposed that a reduction in the number of nephrons is a renal abnormality that plays an important role in the pathogenesis of essential hypertension. The objective of this study was to determine whether renal cortical volume, used as a measure of the number of nephrons, is lower in normotensive subjects with a familial predisposition to develop essential hypertension than in subjects who lack this predisposition. For this purpose, we measured renal cortical volume using electron beam computed tomography in 26 white offspring of two hypertensive parents (OHT; 14 women, 12 men) and 27 white offspring of two normotensive parents (ONT; 13 women, 14 men) who were stabilized on a high sodium diet for 3 days (200 mmol/day). In women, mean age was significantly greater in OHT than ONT (46.1 ± 4.9 [standard deviation] v 41.8 ± 5.1 years, respectively, P = .04). In men, means for age and weight were greater in OHT than ONT (age: 47.1 ± 7.7 v 37.9 ± 8.1 years, P < .01; weight: 90.2 ± 10.7 v 81.1 ± 9.4 kg, P = .03.) In women, mean total cortical volume did not differ significantly between OHT and ONT (156 ± 33.3 v 166 ± 30.9 cc, P = .80). After adjustment for interindividual differences in age, mean total cortical volume remained not significantly different in OHT than ONT (160 ± 29.0 v 162 ± 32.4 cc, P = .83). In men, mean total cortical volume was significantly greater in OHT than ONT (210 ± 33.6 v 180 ± 20.0 cc, P < .01). After adjustment for interindividual differences in age, mean total cortical volume remained significantly greater in OHT than ONT (207 ± 33.2 v 182 ± 19.8 cc, P = .02). After adjustment for interindividual differences in body weight, mean total cortical volume did not differ significantly between OHT and ONT (201 ± 21.7 v 187 ± 20.1 cc, P = .09). The results of this study do not support the hypothesis that a decrease in renal cortical volume, as a result of a decrease in number of nephrons, is a characteristic of white women or men with a familial predisposition to develop essential hypertension.

Original languageEnglish (US)
Pages (from-to)779-786
Number of pages8
JournalAmerican Journal of Hypertension
Volume9
Issue number8 I
DOIs
StatePublished - Aug 1996
Externally publishedYes

Fingerprint

Hypertension
Nephrons
Kidney
Parents
Weights and Measures
X Ray Computed Tomography
Sodium
Body Weight
Diet
Essential Hypertension

Keywords

  • Electron beam computed tomography
  • Essential hypertension
  • Family history
  • Renal volume

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The relationship between renal cortical volume and predisposition to hypertension. / Flickinger, Allen L.; Lerman, Lilach O; Sheedy, Patrick F.; Turner, Stephen T.

In: American Journal of Hypertension, Vol. 9, No. 8 I, 08.1996, p. 779-786.

Research output: Contribution to journalArticle

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abstract = "It has been proposed that a reduction in the number of nephrons is a renal abnormality that plays an important role in the pathogenesis of essential hypertension. The objective of this study was to determine whether renal cortical volume, used as a measure of the number of nephrons, is lower in normotensive subjects with a familial predisposition to develop essential hypertension than in subjects who lack this predisposition. For this purpose, we measured renal cortical volume using electron beam computed tomography in 26 white offspring of two hypertensive parents (OHT; 14 women, 12 men) and 27 white offspring of two normotensive parents (ONT; 13 women, 14 men) who were stabilized on a high sodium diet for 3 days (200 mmol/day). In women, mean age was significantly greater in OHT than ONT (46.1 ± 4.9 [standard deviation] v 41.8 ± 5.1 years, respectively, P = .04). In men, means for age and weight were greater in OHT than ONT (age: 47.1 ± 7.7 v 37.9 ± 8.1 years, P < .01; weight: 90.2 ± 10.7 v 81.1 ± 9.4 kg, P = .03.) In women, mean total cortical volume did not differ significantly between OHT and ONT (156 ± 33.3 v 166 ± 30.9 cc, P = .80). After adjustment for interindividual differences in age, mean total cortical volume remained not significantly different in OHT than ONT (160 ± 29.0 v 162 ± 32.4 cc, P = .83). In men, mean total cortical volume was significantly greater in OHT than ONT (210 ± 33.6 v 180 ± 20.0 cc, P < .01). After adjustment for interindividual differences in age, mean total cortical volume remained significantly greater in OHT than ONT (207 ± 33.2 v 182 ± 19.8 cc, P = .02). After adjustment for interindividual differences in body weight, mean total cortical volume did not differ significantly between OHT and ONT (201 ± 21.7 v 187 ± 20.1 cc, P = .09). The results of this study do not support the hypothesis that a decrease in renal cortical volume, as a result of a decrease in number of nephrons, is a characteristic of white women or men with a familial predisposition to develop essential hypertension.",
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