The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA

Sherry L. Wolf, Debra L. Barton, Rui Qin, Edward J. Wos, Jeff A Sloan, Heshan Liu, Neil K. Aaronson, Daniel V. Satele, Bassam I. Mattar, Nathan B. Green, Charles Lawrence Loprinzi

Research output: Contribution to journalArticle

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Abstract

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is characterized by numbness, tingling, and shooting/burning pain. This analysis was performed to describe the relationship between numbness, tingling, and shooting/burning pain in patients with CIPN, as reported using the EORTC QLQ-CIPN20 (CIPN20). Methods: Baseline CIPN20 data were provided for all patients on a prospective trial designed to treat patients with bothersome CIPN. Baseline frequencies for the items on the CIPN20 are primarily described by descriptive statistics and histograms, with correlational analyses between individual items. Results: A majority of the 199 patients accrued to this study reported "quite a bit" to "very much" numbness (57%) or tingling (63%) in the hands compared to "a little" or "not at all" (numbness (43%), tingling (38%)). Fewer patients reported "quite a bit" to "very much" shooting/burning pain in the hands (18%). Numbness and tingling in the hands were highly correlated (r∈=∈0.69), while neither were highly correlated with shooting/burning pain. Similar results were observed in the feet. More severe ratings for tingling and shooting/burning pain were ascribed to the lower extremities, as opposed to the upper extremities. Conclusions: In patients with CIPN, severe sensory neuropathy symptoms (numbness, tingling) commonly exist without severe neuropathic pain symptoms (shooting/burning pain), while the reverse is not common. Symptoms in the feet should be evaluated distinctly from those in the hands as the experience of symptoms is not identical, for individual patients, in upper versus lower extremities.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalSupportive Care in Cancer
Volume20
Issue number3
DOIs
StatePublished - Mar 2012

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Hypesthesia
Peripheral Nervous System Diseases
Drug Therapy
Pain
Hand
Foot
Lower Extremity
Neuralgia
Upper Extremity

Keywords

  • Chemotherapy-induced peripheral neuropathy
  • Cytotoxic agents
  • EORTC QLQ CIPN20
  • Numbness
  • Shooting/burning pain
  • Tingling

ASJC Scopus subject areas

  • Oncology

Cite this

The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA. / Wolf, Sherry L.; Barton, Debra L.; Qin, Rui; Wos, Edward J.; Sloan, Jeff A; Liu, Heshan; Aaronson, Neil K.; Satele, Daniel V.; Mattar, Bassam I.; Green, Nathan B.; Loprinzi, Charles Lawrence.

In: Supportive Care in Cancer, Vol. 20, No. 3, 03.2012, p. 625-632.

Research output: Contribution to journalArticle

Wolf, Sherry L. ; Barton, Debra L. ; Qin, Rui ; Wos, Edward J. ; Sloan, Jeff A ; Liu, Heshan ; Aaronson, Neil K. ; Satele, Daniel V. ; Mattar, Bassam I. ; Green, Nathan B. ; Loprinzi, Charles Lawrence. / The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA. In: Supportive Care in Cancer. 2012 ; Vol. 20, No. 3. pp. 625-632.
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abstract = "Background: Chemotherapy-induced peripheral neuropathy (CIPN) is characterized by numbness, tingling, and shooting/burning pain. This analysis was performed to describe the relationship between numbness, tingling, and shooting/burning pain in patients with CIPN, as reported using the EORTC QLQ-CIPN20 (CIPN20). Methods: Baseline CIPN20 data were provided for all patients on a prospective trial designed to treat patients with bothersome CIPN. Baseline frequencies for the items on the CIPN20 are primarily described by descriptive statistics and histograms, with correlational analyses between individual items. Results: A majority of the 199 patients accrued to this study reported {"}quite a bit{"} to {"}very much{"} numbness (57{\%}) or tingling (63{\%}) in the hands compared to {"}a little{"} or {"}not at all{"} (numbness (43{\%}), tingling (38{\%})). Fewer patients reported {"}quite a bit{"} to {"}very much{"} shooting/burning pain in the hands (18{\%}). Numbness and tingling in the hands were highly correlated (r∈=∈0.69), while neither were highly correlated with shooting/burning pain. Similar results were observed in the feet. More severe ratings for tingling and shooting/burning pain were ascribed to the lower extremities, as opposed to the upper extremities. Conclusions: In patients with CIPN, severe sensory neuropathy symptoms (numbness, tingling) commonly exist without severe neuropathic pain symptoms (shooting/burning pain), while the reverse is not common. Symptoms in the feet should be evaluated distinctly from those in the hands as the experience of symptoms is not identical, for individual patients, in upper versus lower extremities.",
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AU - Wolf, Sherry L.

AU - Barton, Debra L.

AU - Qin, Rui

AU - Wos, Edward J.

AU - Sloan, Jeff A

AU - Liu, Heshan

AU - Aaronson, Neil K.

AU - Satele, Daniel V.

AU - Mattar, Bassam I.

AU - Green, Nathan B.

AU - Loprinzi, Charles Lawrence

PY - 2012/3

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N2 - Background: Chemotherapy-induced peripheral neuropathy (CIPN) is characterized by numbness, tingling, and shooting/burning pain. This analysis was performed to describe the relationship between numbness, tingling, and shooting/burning pain in patients with CIPN, as reported using the EORTC QLQ-CIPN20 (CIPN20). Methods: Baseline CIPN20 data were provided for all patients on a prospective trial designed to treat patients with bothersome CIPN. Baseline frequencies for the items on the CIPN20 are primarily described by descriptive statistics and histograms, with correlational analyses between individual items. Results: A majority of the 199 patients accrued to this study reported "quite a bit" to "very much" numbness (57%) or tingling (63%) in the hands compared to "a little" or "not at all" (numbness (43%), tingling (38%)). Fewer patients reported "quite a bit" to "very much" shooting/burning pain in the hands (18%). Numbness and tingling in the hands were highly correlated (r∈=∈0.69), while neither were highly correlated with shooting/burning pain. Similar results were observed in the feet. More severe ratings for tingling and shooting/burning pain were ascribed to the lower extremities, as opposed to the upper extremities. Conclusions: In patients with CIPN, severe sensory neuropathy symptoms (numbness, tingling) commonly exist without severe neuropathic pain symptoms (shooting/burning pain), while the reverse is not common. Symptoms in the feet should be evaluated distinctly from those in the hands as the experience of symptoms is not identical, for individual patients, in upper versus lower extremities.

AB - Background: Chemotherapy-induced peripheral neuropathy (CIPN) is characterized by numbness, tingling, and shooting/burning pain. This analysis was performed to describe the relationship between numbness, tingling, and shooting/burning pain in patients with CIPN, as reported using the EORTC QLQ-CIPN20 (CIPN20). Methods: Baseline CIPN20 data were provided for all patients on a prospective trial designed to treat patients with bothersome CIPN. Baseline frequencies for the items on the CIPN20 are primarily described by descriptive statistics and histograms, with correlational analyses between individual items. Results: A majority of the 199 patients accrued to this study reported "quite a bit" to "very much" numbness (57%) or tingling (63%) in the hands compared to "a little" or "not at all" (numbness (43%), tingling (38%)). Fewer patients reported "quite a bit" to "very much" shooting/burning pain in the hands (18%). Numbness and tingling in the hands were highly correlated (r∈=∈0.69), while neither were highly correlated with shooting/burning pain. Similar results were observed in the feet. More severe ratings for tingling and shooting/burning pain were ascribed to the lower extremities, as opposed to the upper extremities. Conclusions: In patients with CIPN, severe sensory neuropathy symptoms (numbness, tingling) commonly exist without severe neuropathic pain symptoms (shooting/burning pain), while the reverse is not common. Symptoms in the feet should be evaluated distinctly from those in the hands as the experience of symptoms is not identical, for individual patients, in upper versus lower extremities.

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KW - Cytotoxic agents

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KW - Shooting/burning pain

KW - Tingling

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