The relationship between leptin and ventilatory control in heart failure

Ivan Cundrle, Virend Somers, Prachi Singh, Bruce David Johnson, Christopher G. Scott, Lyle J. Olson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluated the relationship of circulating leptin concentration with exercise ventilation in HF patients. Methods and Results Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptin concentration of 1.8 ± 8.9 ng/mL and a highest of 33.3 ± 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 ± 6 vs 34 ± 4; P <01) as well as in the highest (38 ± 8 vs 34 ± 4; P <05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to VE/VCO2 in the low-to-normal quintiles (β = -0.64; P <01), positively in the normal-to-high quintiles (β = 0.52; P =.02), and positively correlated to PETCO2 in the low-to-normal quintiles (β = 0.59; P =.01) and inversely in the normal-to-high quintiles (β = -0.53; P =.02). Conclusions In HF patients, both high and low leptin concentrations are associated with increased VE/VCO2 and decreased PETCO 2 with a nonlinear U-shaped relationship, suggesting that either leptin deficiency or leptin resistance may modulate ventilatory control in HF patients.

Original languageEnglish (US)
Pages (from-to)756-761
Number of pages6
JournalJournal of Cardiac Failure
Volume19
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Leptin
Heart Failure
Ventilation
Exercise
Body Mass Index
Animal Models
Regression Analysis

Keywords

  • Cardiopulmonary exercise testing
  • leptin resistance
  • ventilatory efficiency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The relationship between leptin and ventilatory control in heart failure. / Cundrle, Ivan; Somers, Virend; Singh, Prachi; Johnson, Bruce David; Scott, Christopher G.; Olson, Lyle J.

In: Journal of Cardiac Failure, Vol. 19, No. 11, 11.2013, p. 756-761.

Research output: Contribution to journalArticle

@article{aea8ee102a114a5e830c4d0cc0c1222d,
title = "The relationship between leptin and ventilatory control in heart failure",
abstract = "Background Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluated the relationship of circulating leptin concentration with exercise ventilation in HF patients. Methods and Results Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptin concentration of 1.8 ± 8.9 ng/mL and a highest of 33.3 ± 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 ± 6 vs 34 ± 4; P <01) as well as in the highest (38 ± 8 vs 34 ± 4; P <05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to VE/VCO2 in the low-to-normal quintiles (β = -0.64; P <01), positively in the normal-to-high quintiles (β = 0.52; P =.02), and positively correlated to PETCO2 in the low-to-normal quintiles (β = 0.59; P =.01) and inversely in the normal-to-high quintiles (β = -0.53; P =.02). Conclusions In HF patients, both high and low leptin concentrations are associated with increased VE/VCO2 and decreased PETCO 2 with a nonlinear U-shaped relationship, suggesting that either leptin deficiency or leptin resistance may modulate ventilatory control in HF patients.",
keywords = "Cardiopulmonary exercise testing, leptin resistance, ventilatory efficiency",
author = "Ivan Cundrle and Virend Somers and Prachi Singh and Johnson, {Bruce David} and Scott, {Christopher G.} and Olson, {Lyle J.}",
year = "2013",
month = "11",
doi = "10.1016/j.cardfail.2013.10.004",
language = "English (US)",
volume = "19",
pages = "756--761",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
number = "11",

}

TY - JOUR

T1 - The relationship between leptin and ventilatory control in heart failure

AU - Cundrle, Ivan

AU - Somers, Virend

AU - Singh, Prachi

AU - Johnson, Bruce David

AU - Scott, Christopher G.

AU - Olson, Lyle J.

PY - 2013/11

Y1 - 2013/11

N2 - Background Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluated the relationship of circulating leptin concentration with exercise ventilation in HF patients. Methods and Results Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptin concentration of 1.8 ± 8.9 ng/mL and a highest of 33.3 ± 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 ± 6 vs 34 ± 4; P <01) as well as in the highest (38 ± 8 vs 34 ± 4; P <05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to VE/VCO2 in the low-to-normal quintiles (β = -0.64; P <01), positively in the normal-to-high quintiles (β = 0.52; P =.02), and positively correlated to PETCO2 in the low-to-normal quintiles (β = 0.59; P =.01) and inversely in the normal-to-high quintiles (β = -0.53; P =.02). Conclusions In HF patients, both high and low leptin concentrations are associated with increased VE/VCO2 and decreased PETCO 2 with a nonlinear U-shaped relationship, suggesting that either leptin deficiency or leptin resistance may modulate ventilatory control in HF patients.

AB - Background Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluated the relationship of circulating leptin concentration with exercise ventilation in HF patients. Methods and Results Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptin concentration of 1.8 ± 8.9 ng/mL and a highest of 33.3 ± 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 ± 6 vs 34 ± 4; P <01) as well as in the highest (38 ± 8 vs 34 ± 4; P <05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to VE/VCO2 in the low-to-normal quintiles (β = -0.64; P <01), positively in the normal-to-high quintiles (β = 0.52; P =.02), and positively correlated to PETCO2 in the low-to-normal quintiles (β = 0.59; P =.01) and inversely in the normal-to-high quintiles (β = -0.53; P =.02). Conclusions In HF patients, both high and low leptin concentrations are associated with increased VE/VCO2 and decreased PETCO 2 with a nonlinear U-shaped relationship, suggesting that either leptin deficiency or leptin resistance may modulate ventilatory control in HF patients.

KW - Cardiopulmonary exercise testing

KW - leptin resistance

KW - ventilatory efficiency

UR - http://www.scopus.com/inward/record.url?scp=84888021522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888021522&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2013.10.004

DO - 10.1016/j.cardfail.2013.10.004

M3 - Article

C2 - 24263120

AN - SCOPUS:84888021522

VL - 19

SP - 756

EP - 761

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 11

ER -