The relationship between histopathological features of progressive supranuclear palsy and disease duration

Keith A. Josephs; Jayawant N. Mandrekar; Dennis W. Dickson

doi:10.1016/j.parkreldis.2005.08.007

The relationship between histopathological features of progressive supranuclear palsy and disease duration

Keith A. Josephs, Jayawant N. Mandrekar, Dennis W. Dickson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Progressive supranuclear palsy (PSP) is a distinct clinicopathological entity characterized by neurofibrillary tangles, tufted astrocytes, threads and oligodendroglial coiled bodies. These four lesions are distributed in varying densities throughout subcortical and brainstem structures. There is no data regarding the relationship of disease duration to lesion burden severity in PSP. We report the results of analysis of semiquantitative data collected as part of the diagnostic evaluation on 97 cases of 'pure' PSP, submitted to the Society of PSP Brain Bank. Surprisingly, the data suggests that in PSP as duration of illness increases there is a decrease in oligodendroglial tau burden.

Original language	English (US)
Pages (from-to)	109-112
Number of pages	4
Journal	Parkinsonism and Related Disorders
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.parkreldis.2005.08.007
State	Published - Mar 2006

Keywords

Neurofibrillary tangles
Oligodendroglial coiled bodies
Progressive supranuclear palsy
Threads
Tufted astrocytes

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2005.08.007

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title = "The relationship between histopathological features of progressive supranuclear palsy and disease duration",

abstract = "Progressive supranuclear palsy (PSP) is a distinct clinicopathological entity characterized by neurofibrillary tangles, tufted astrocytes, threads and oligodendroglial coiled bodies. These four lesions are distributed in varying densities throughout subcortical and brainstem structures. There is no data regarding the relationship of disease duration to lesion burden severity in PSP. We report the results of analysis of semiquantitative data collected as part of the diagnostic evaluation on 97 cases of 'pure' PSP, submitted to the Society of PSP Brain Bank. Surprisingly, the data suggests that in PSP as duration of illness increases there is a decrease in oligodendroglial tau burden.",

keywords = "Neurofibrillary tangles, Oligodendroglial coiled bodies, Progressive supranuclear palsy, Threads, Tufted astrocytes",

author = "Josephs, {Keith A.} and Mandrekar, {Jayawant N.} and Dickson, {Dennis W.}",

note = "Funding Information: This study was possible through the support of the Society for Progressive Supranuclear Palsy and was also supported in part by the National Institutes of Health (P50-AG16574, R01-AG17216, P01-AG14449, P01-AG3949, and P50-NS40256), and the Clarice Smith Research Programs of the Mayo Foundation. This study was an oral presentation at the 9th International Congress of Parkinson's Disease and Movement Disorders, New Orleans, Louisiana, USA. March 5–8, 2005.",

year = "2006",

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doi = "10.1016/j.parkreldis.2005.08.007",

language = "English (US)",

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AU - Josephs, Keith A.

AU - Mandrekar, Jayawant N.

AU - Dickson, Dennis W.

N1 - Funding Information: This study was possible through the support of the Society for Progressive Supranuclear Palsy and was also supported in part by the National Institutes of Health (P50-AG16574, R01-AG17216, P01-AG14449, P01-AG3949, and P50-NS40256), and the Clarice Smith Research Programs of the Mayo Foundation. This study was an oral presentation at the 9th International Congress of Parkinson's Disease and Movement Disorders, New Orleans, Louisiana, USA. March 5–8, 2005.

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N2 - Progressive supranuclear palsy (PSP) is a distinct clinicopathological entity characterized by neurofibrillary tangles, tufted astrocytes, threads and oligodendroglial coiled bodies. These four lesions are distributed in varying densities throughout subcortical and brainstem structures. There is no data regarding the relationship of disease duration to lesion burden severity in PSP. We report the results of analysis of semiquantitative data collected as part of the diagnostic evaluation on 97 cases of 'pure' PSP, submitted to the Society of PSP Brain Bank. Surprisingly, the data suggests that in PSP as duration of illness increases there is a decrease in oligodendroglial tau burden.

AB - Progressive supranuclear palsy (PSP) is a distinct clinicopathological entity characterized by neurofibrillary tangles, tufted astrocytes, threads and oligodendroglial coiled bodies. These four lesions are distributed in varying densities throughout subcortical and brainstem structures. There is no data regarding the relationship of disease duration to lesion burden severity in PSP. We report the results of analysis of semiquantitative data collected as part of the diagnostic evaluation on 97 cases of 'pure' PSP, submitted to the Society of PSP Brain Bank. Surprisingly, the data suggests that in PSP as duration of illness increases there is a decrease in oligodendroglial tau burden.

KW - Neurofibrillary tangles

KW - Oligodendroglial coiled bodies

KW - Progressive supranuclear palsy

KW - Threads

KW - Tufted astrocytes

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The relationship between histopathological features of progressive supranuclear palsy and disease duration

Abstract

Keywords

ASJC Scopus subject areas

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