The Relationship Between Headaches with Epileptic and Non-epileptic Seizures: a Narrative Review

William S. Kingston, Todd J Schwedt

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Purpose of Review: The purpose of this review is to examine the relationship between headaches and epilepsy as well as headaches and psychogenic non-epileptic seizures (PNES). Emphasis was placed on clinical characteristics, pathophysiology, and treatment. Recent Findings: Epilepsy and headaches are common disorders that co-occur more often than would be expected by chance. There are some overlapping clinical features between migraine and epilepsy as well as evidence for shared underlying mechanisms. Proposed theories for a shared etiology include ion channel dysfunction, glutamatergic mechanisms, and mitochondrial dysfunction. Some, but not all, recent diagnostic classification systems have recognized the relationship between headaches and epilepsy. Ictal headaches are rare and should raise suspicion for PNES. Headaches in patients with epilepsy are undertreated despite evidence for efficacy of abortive headache medications. Summary: Comorbid headaches and epilepsy are relatively common in the population presenting to a neurologist. Patients who have headaches and epilepsy and/or PNES should receive appropriate treatment that often includes mutually beneficial preventative therapy and includes abortive headache treatment.

Original languageEnglish (US)
Article number17
JournalCurrent Pain and Headache Reports
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Headache
Seizures
Epilepsy
Tension-Type Headache
Headache Disorders
Therapeutics
Migraine Disorders
Ion Channels
Stroke
Population

Keywords

  • Epilepsy
  • Headache
  • Migraine
  • PNES
  • Seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

The Relationship Between Headaches with Epileptic and Non-epileptic Seizures : a Narrative Review. / Kingston, William S.; Schwedt, Todd J.

In: Current Pain and Headache Reports, Vol. 21, No. 3, 17, 01.03.2017.

Research output: Contribution to journalReview article

@article{1fa36298264a483cb04eb517c004dc89,
title = "The Relationship Between Headaches with Epileptic and Non-epileptic Seizures: a Narrative Review",
abstract = "Purpose of Review: The purpose of this review is to examine the relationship between headaches and epilepsy as well as headaches and psychogenic non-epileptic seizures (PNES). Emphasis was placed on clinical characteristics, pathophysiology, and treatment. Recent Findings: Epilepsy and headaches are common disorders that co-occur more often than would be expected by chance. There are some overlapping clinical features between migraine and epilepsy as well as evidence for shared underlying mechanisms. Proposed theories for a shared etiology include ion channel dysfunction, glutamatergic mechanisms, and mitochondrial dysfunction. Some, but not all, recent diagnostic classification systems have recognized the relationship between headaches and epilepsy. Ictal headaches are rare and should raise suspicion for PNES. Headaches in patients with epilepsy are undertreated despite evidence for efficacy of abortive headache medications. Summary: Comorbid headaches and epilepsy are relatively common in the population presenting to a neurologist. Patients who have headaches and epilepsy and/or PNES should receive appropriate treatment that often includes mutually beneficial preventative therapy and includes abortive headache treatment.",
keywords = "Epilepsy, Headache, Migraine, PNES, Seizures",
author = "Kingston, {William S.} and Schwedt, {Todd J}",
year = "2017",
month = "3",
day = "1",
doi = "10.1007/s11916-017-0617-9",
language = "English (US)",
volume = "21",
journal = "Current Pain and Headache Reports",
issn = "1531-3433",
publisher = "Current Science, Inc.",
number = "3",

}

TY - JOUR

T1 - The Relationship Between Headaches with Epileptic and Non-epileptic Seizures

T2 - a Narrative Review

AU - Kingston, William S.

AU - Schwedt, Todd J

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Purpose of Review: The purpose of this review is to examine the relationship between headaches and epilepsy as well as headaches and psychogenic non-epileptic seizures (PNES). Emphasis was placed on clinical characteristics, pathophysiology, and treatment. Recent Findings: Epilepsy and headaches are common disorders that co-occur more often than would be expected by chance. There are some overlapping clinical features between migraine and epilepsy as well as evidence for shared underlying mechanisms. Proposed theories for a shared etiology include ion channel dysfunction, glutamatergic mechanisms, and mitochondrial dysfunction. Some, but not all, recent diagnostic classification systems have recognized the relationship between headaches and epilepsy. Ictal headaches are rare and should raise suspicion for PNES. Headaches in patients with epilepsy are undertreated despite evidence for efficacy of abortive headache medications. Summary: Comorbid headaches and epilepsy are relatively common in the population presenting to a neurologist. Patients who have headaches and epilepsy and/or PNES should receive appropriate treatment that often includes mutually beneficial preventative therapy and includes abortive headache treatment.

AB - Purpose of Review: The purpose of this review is to examine the relationship between headaches and epilepsy as well as headaches and psychogenic non-epileptic seizures (PNES). Emphasis was placed on clinical characteristics, pathophysiology, and treatment. Recent Findings: Epilepsy and headaches are common disorders that co-occur more often than would be expected by chance. There are some overlapping clinical features between migraine and epilepsy as well as evidence for shared underlying mechanisms. Proposed theories for a shared etiology include ion channel dysfunction, glutamatergic mechanisms, and mitochondrial dysfunction. Some, but not all, recent diagnostic classification systems have recognized the relationship between headaches and epilepsy. Ictal headaches are rare and should raise suspicion for PNES. Headaches in patients with epilepsy are undertreated despite evidence for efficacy of abortive headache medications. Summary: Comorbid headaches and epilepsy are relatively common in the population presenting to a neurologist. Patients who have headaches and epilepsy and/or PNES should receive appropriate treatment that often includes mutually beneficial preventative therapy and includes abortive headache treatment.

KW - Epilepsy

KW - Headache

KW - Migraine

KW - PNES

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=85014895290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014895290&partnerID=8YFLogxK

U2 - 10.1007/s11916-017-0617-9

DO - 10.1007/s11916-017-0617-9

M3 - Review article

C2 - 28271336

AN - SCOPUS:85014895290

VL - 21

JO - Current Pain and Headache Reports

JF - Current Pain and Headache Reports

SN - 1531-3433

IS - 3

M1 - 17

ER -