The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing

J. K. Dibaise, N. Patel, J. Noelting, Amylou Dueck, M. Roarke, M. D. Crowell

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Symptoms suggestive of gastroparesis are non-specific and conflicting reports exist regarding the ability of symptoms to predict the presence of gastroparesis. Our aim, therefore, was to evaluate the relationships between gastroparetic symptoms and their impact on quality of life and determine their relationship with clinical factors and gastric emptying. Methods: Gastric emptying scintigraphy, sociodemographic features, health care resource utilization, gastroparetic symptoms, and quality of life using validated questionnaires were obtained from consecutive patients referred for gastric emptying testing (GET). Descriptive analyses were conducted and logistic regression was performed to evaluate associations with abnormal gastric emptying after controlling for other covariates. Key Results: Two hundred and sixty-six patients participated (195 females; mean age, 49.1 ± 17.6 years); 75% met Rome III criteria for functional dyspepsia. Gastric emptying was delayed in 28.2% at 4 h; the delay was mild in 48%, moderate in 20% and severe in 32%. Nausea/emesis and postprandial fullness, but not bloating, were significantly greater in those with delayed emptying. Postprandial fullness was most severe. Weak correlations were identified between symptom severity and the severity of gastric emptying delay. Quality of life was also lower in the delayed emptying group. Logistic regression analysis demonstrated associations between delayed gastric emptying and lower quality of life and increased symptom severity. Conclusions & Inferences: In patients referred for GET, gastroparetic symptoms were more severe in those with delayed emptying. A decrease in quality of life in those with delayed gastric emptying was also present; this was not related to the severity of the delay in gastric emptying.

Original languageEnglish (US)
Pages (from-to)234-242
Number of pages9
JournalNeurogastroenterology and Motility
Volume28
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Gastric Emptying
Quality of Life
Gastroparesis
Logistic Models
Patient Acceptance of Health Care
Health Resources
Dyspepsia
Radionuclide Imaging
Nausea
Vomiting
Regression Analysis

Keywords

  • Functional dyspepsia
  • Gastroparesis
  • Quality of life
  • Symptoms

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing. / Dibaise, J. K.; Patel, N.; Noelting, J.; Dueck, Amylou; Roarke, M.; Crowell, M. D.

In: Neurogastroenterology and Motility, Vol. 28, No. 2, 01.02.2016, p. 234-242.

Research output: Contribution to journalArticle

@article{007c9811964f4dd7b15a5db5f9c0b519,
title = "The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing",
abstract = "Background: Symptoms suggestive of gastroparesis are non-specific and conflicting reports exist regarding the ability of symptoms to predict the presence of gastroparesis. Our aim, therefore, was to evaluate the relationships between gastroparetic symptoms and their impact on quality of life and determine their relationship with clinical factors and gastric emptying. Methods: Gastric emptying scintigraphy, sociodemographic features, health care resource utilization, gastroparetic symptoms, and quality of life using validated questionnaires were obtained from consecutive patients referred for gastric emptying testing (GET). Descriptive analyses were conducted and logistic regression was performed to evaluate associations with abnormal gastric emptying after controlling for other covariates. Key Results: Two hundred and sixty-six patients participated (195 females; mean age, 49.1 ± 17.6 years); 75{\%} met Rome III criteria for functional dyspepsia. Gastric emptying was delayed in 28.2{\%} at 4 h; the delay was mild in 48{\%}, moderate in 20{\%} and severe in 32{\%}. Nausea/emesis and postprandial fullness, but not bloating, were significantly greater in those with delayed emptying. Postprandial fullness was most severe. Weak correlations were identified between symptom severity and the severity of gastric emptying delay. Quality of life was also lower in the delayed emptying group. Logistic regression analysis demonstrated associations between delayed gastric emptying and lower quality of life and increased symptom severity. Conclusions & Inferences: In patients referred for GET, gastroparetic symptoms were more severe in those with delayed emptying. A decrease in quality of life in those with delayed gastric emptying was also present; this was not related to the severity of the delay in gastric emptying.",
keywords = "Functional dyspepsia, Gastroparesis, Quality of life, Symptoms",
author = "Dibaise, {J. K.} and N. Patel and J. Noelting and Amylou Dueck and M. Roarke and Crowell, {M. D.}",
year = "2016",
month = "2",
day = "1",
doi = "10.1111/nmo.12718",
language = "English (US)",
volume = "28",
pages = "234--242",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing

AU - Dibaise, J. K.

AU - Patel, N.

AU - Noelting, J.

AU - Dueck, Amylou

AU - Roarke, M.

AU - Crowell, M. D.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: Symptoms suggestive of gastroparesis are non-specific and conflicting reports exist regarding the ability of symptoms to predict the presence of gastroparesis. Our aim, therefore, was to evaluate the relationships between gastroparetic symptoms and their impact on quality of life and determine their relationship with clinical factors and gastric emptying. Methods: Gastric emptying scintigraphy, sociodemographic features, health care resource utilization, gastroparetic symptoms, and quality of life using validated questionnaires were obtained from consecutive patients referred for gastric emptying testing (GET). Descriptive analyses were conducted and logistic regression was performed to evaluate associations with abnormal gastric emptying after controlling for other covariates. Key Results: Two hundred and sixty-six patients participated (195 females; mean age, 49.1 ± 17.6 years); 75% met Rome III criteria for functional dyspepsia. Gastric emptying was delayed in 28.2% at 4 h; the delay was mild in 48%, moderate in 20% and severe in 32%. Nausea/emesis and postprandial fullness, but not bloating, were significantly greater in those with delayed emptying. Postprandial fullness was most severe. Weak correlations were identified between symptom severity and the severity of gastric emptying delay. Quality of life was also lower in the delayed emptying group. Logistic regression analysis demonstrated associations between delayed gastric emptying and lower quality of life and increased symptom severity. Conclusions & Inferences: In patients referred for GET, gastroparetic symptoms were more severe in those with delayed emptying. A decrease in quality of life in those with delayed gastric emptying was also present; this was not related to the severity of the delay in gastric emptying.

AB - Background: Symptoms suggestive of gastroparesis are non-specific and conflicting reports exist regarding the ability of symptoms to predict the presence of gastroparesis. Our aim, therefore, was to evaluate the relationships between gastroparetic symptoms and their impact on quality of life and determine their relationship with clinical factors and gastric emptying. Methods: Gastric emptying scintigraphy, sociodemographic features, health care resource utilization, gastroparetic symptoms, and quality of life using validated questionnaires were obtained from consecutive patients referred for gastric emptying testing (GET). Descriptive analyses were conducted and logistic regression was performed to evaluate associations with abnormal gastric emptying after controlling for other covariates. Key Results: Two hundred and sixty-six patients participated (195 females; mean age, 49.1 ± 17.6 years); 75% met Rome III criteria for functional dyspepsia. Gastric emptying was delayed in 28.2% at 4 h; the delay was mild in 48%, moderate in 20% and severe in 32%. Nausea/emesis and postprandial fullness, but not bloating, were significantly greater in those with delayed emptying. Postprandial fullness was most severe. Weak correlations were identified between symptom severity and the severity of gastric emptying delay. Quality of life was also lower in the delayed emptying group. Logistic regression analysis demonstrated associations between delayed gastric emptying and lower quality of life and increased symptom severity. Conclusions & Inferences: In patients referred for GET, gastroparetic symptoms were more severe in those with delayed emptying. A decrease in quality of life in those with delayed gastric emptying was also present; this was not related to the severity of the delay in gastric emptying.

KW - Functional dyspepsia

KW - Gastroparesis

KW - Quality of life

KW - Symptoms

UR - http://www.scopus.com/inward/record.url?scp=84956734265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956734265&partnerID=8YFLogxK

U2 - 10.1111/nmo.12718

DO - 10.1111/nmo.12718

M3 - Article

C2 - 26547484

AN - SCOPUS:84956734265

VL - 28

SP - 234

EP - 242

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 2

ER -