The regulation of mitotic nuclear envelope breakdown: a role for multiple lamin kinases.

Alan P Fields, L. J. Thompson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The chapter reviews the structure and function of the nuclear envelope and describes its dynamic structural changes during cell cycle. Particular emphasis is placed on the regulation of mitotic nuclear envelope breakdown (NEBD), the process by which the physical barrier between cytoplasm and nucleus is dissolved to allow for cell division. The literature suggesting the involvement of multiple protein kinases in NEBD is reviewed and evidence is presented that multiple mitotic lamin kinases, including p34cdc2/cyclin B kinase and protein kinase C, play key roles in mitotic nuclear lamina disassembly. Finally, a model for regulation of mitotic nuclear lamina disassembly by multi-site phosphorylation is described.

Original languageEnglish (US)
Pages (from-to)271-286
Number of pages16
JournalProgress in cell cycle research
Volume1
StatePublished - 1995
Externally publishedYes

Fingerprint

Lamins
Nuclear Envelope
Nuclear Lamina
Phosphotransferases
Cyclin B
Architectural Accessibility
Cell Division
Protein Kinases
Cell Cycle
Cytoplasm
Phosphorylation

Cite this

The regulation of mitotic nuclear envelope breakdown : a role for multiple lamin kinases. / Fields, Alan P; Thompson, L. J.

In: Progress in cell cycle research, Vol. 1, 1995, p. 271-286.

Research output: Contribution to journalArticle

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