The (re)emergence of B cells in organ transplantation

Mark D. Stegall, Suresh Raghavaiah, James M. Gloor

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Purpose of Review: To outline recent advances in our understanding of the role of B cells in transplantation. Recent Findings: While T-cell-mediated alloimmunity has been largely controlled using immunosuppression, the role of B cells in transplantation is just beginning to be understood. Recent studies have outlined some of the important clinical issues involving antibody including early acute humoral rejection and late transplant glomerulopathy. In addition, recent studies have identified bone-marrow-derived long-lived plasma cells that appear to be a major source of donor-specific alloantibody in sensitized renal transplant recipients. New agents are being tested that deplete these cells in vitro and in vivo. Memory B cells appear to be important in early acute humoral rejection, but few basic studies have been performed. Finally, recent studies involving patients undergoing tolerogenic regimens suggest that T-cell tolerance does not always convey tolerance in naive B cells. Summary: Several B cell types have clear and specific roles in transplant recipients. Although our understanding of B cells in transplantation has improved, important gaps remain.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
JournalCurrent opinion in organ transplantation
Volume15
Issue number4
DOIs
StatePublished - Aug 1 2010

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Keywords

  • B cells
  • antibody-mediated rejection
  • kidney transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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