The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus

Robert A. Brown, Jonathon H. Gralewski, Raymund R. Razonable

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.

Original languageEnglish (US)
Pages (from-to)e96-e99
JournalClinical Infectious Diseases
Volume49
Issue number9
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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