@article{3f0130d01f34456885352d078f4659b0,
title = "The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus",
abstract = "Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.",
author = "Brown, {Robert A.} and Gralewski, {Jonathon H.} and Razonable, {Raymund R.}",
note = "Funding Information: Financial support. Mayo Clinic Department of Medicine (to R.R.R.); Transplant Center Scholarly Award of the William J von Leibig Transplant Center (to R.R.R.); Mayo CR20 Award (to R.R.R.); and the National Center for Research Resources (grant 1 UL1 RR024150), a component of the National Institutes of Health, and the National Institutes of Health Roadmap for Medical Research. Potential conflicts of interest. All authors: no conflicts.",
year = "2009",
month = nov,
doi = "10.1086/644501",
language = "English (US)",
volume = "49",
pages = "e96--e99",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "9",
}