Abstract
Myocarditis is a diverse group of heart-specific immune processes classified by clinical and histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with inflammation or viral infection. Recent experimental studies revealed complex regulatory roles for several microribonucleic acids and T-cell and macrophage subtypes. Although the prevalence of myocarditis remained stable between 1990 and 2013 at about 22 per 100,000 people, overall mortality from cardiomyopathy and myocarditis has decreased since 2005. The diagnostic and prognostic value of cardiac magnetic resonance has increased with new, higher-sensitivity sequences. Positron emission tomography has emerged as a useful tool for diagnosis of cardiac sarcoidosis. The sensitivity of endomyocardial biopsy may be increased, especially in suspected sarcoidosis, by the use of electrogram guidance to target regions of abnormal signal. Investigational treatments on the basis of mechanistic advances are entering clinical trials. Revised management recommendations regarding athletic participation after acute myocarditis have heightened the importance of early diagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2348-2364 |
| Number of pages | 17 |
| Journal | Journal of the American College of Cardiology |
| Volume | 68 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 29 2016 |
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Keywords
- heart failure
- inflammasomes
- macrophages
- microRNAs
- sarcoidosis
- t-lymphocyte subsets
- viral infection
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy. / Heymans, Stephane; Eriksson, Urs; Lehtonen, Jukka; Cooper, Leslie T Jr.
In: Journal of the American College of Cardiology, Vol. 68, No. 21, 29.11.2016, p. 2348-2364.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy
AU - Heymans, Stephane
AU - Eriksson, Urs
AU - Lehtonen, Jukka
AU - Cooper, Leslie T Jr.
PY - 2016/11/29
Y1 - 2016/11/29
N2 - Myocarditis is a diverse group of heart-specific immune processes classified by clinical and histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with inflammation or viral infection. Recent experimental studies revealed complex regulatory roles for several microribonucleic acids and T-cell and macrophage subtypes. Although the prevalence of myocarditis remained stable between 1990 and 2013 at about 22 per 100,000 people, overall mortality from cardiomyopathy and myocarditis has decreased since 2005. The diagnostic and prognostic value of cardiac magnetic resonance has increased with new, higher-sensitivity sequences. Positron emission tomography has emerged as a useful tool for diagnosis of cardiac sarcoidosis. The sensitivity of endomyocardial biopsy may be increased, especially in suspected sarcoidosis, by the use of electrogram guidance to target regions of abnormal signal. Investigational treatments on the basis of mechanistic advances are entering clinical trials. Revised management recommendations regarding athletic participation after acute myocarditis have heightened the importance of early diagnosis.
AB - Myocarditis is a diverse group of heart-specific immune processes classified by clinical and histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with inflammation or viral infection. Recent experimental studies revealed complex regulatory roles for several microribonucleic acids and T-cell and macrophage subtypes. Although the prevalence of myocarditis remained stable between 1990 and 2013 at about 22 per 100,000 people, overall mortality from cardiomyopathy and myocarditis has decreased since 2005. The diagnostic and prognostic value of cardiac magnetic resonance has increased with new, higher-sensitivity sequences. Positron emission tomography has emerged as a useful tool for diagnosis of cardiac sarcoidosis. The sensitivity of endomyocardial biopsy may be increased, especially in suspected sarcoidosis, by the use of electrogram guidance to target regions of abnormal signal. Investigational treatments on the basis of mechanistic advances are entering clinical trials. Revised management recommendations regarding athletic participation after acute myocarditis have heightened the importance of early diagnosis.
KW - heart failure
KW - inflammasomes
KW - macrophages
KW - microRNAs
KW - sarcoidosis
KW - t-lymphocyte subsets
KW - viral infection
UR - http://www.scopus.com/inward/record.url?scp=84997824398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84997824398&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2016.09.937
DO - 10.1016/j.jacc.2016.09.937
M3 - Review article
C2 - 27884253
AN - SCOPUS:84997824398
VL - 68
SP - 2348
EP - 2364
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 21
ER -