TY - JOUR
T1 - The provisional OMERACT ultrasonography score for giant cell arteritis
AU - Dejaco, Christian
AU - Ponte, Cristina
AU - Monti, Sara
AU - Rozza, Davide
AU - Scirè, Carlo Alberto
AU - Terslev, Lene
AU - Bruyn, George A.W.
AU - Boumans, Dennis
AU - Hartung, Wolfgang
AU - Hočevar, Alojzija
AU - Milchert, Marcin
AU - Døhn, Uffe Møller
AU - Mukhtyar, Chetan B.
AU - Aschwanden, Markus
AU - Bosch, Philipp
AU - Camellino, Dario
AU - Chrysidis, Stavros
AU - Ciancio, Giovanni
AU - D'Agostino, Maria Antonietta
AU - Daikeler, Thomas
AU - Dasgupta, Bhaskar
AU - De Miguel, Eugenio
AU - Diamantopoulos, Andreas P.
AU - Duftner, Christina
AU - Agueda, Ana
AU - Fredberg, Ulrich
AU - Hanova, Petra
AU - Hansen, Ib Tønder
AU - Hauge, Ellen Margrethe
AU - Iagnocco, Annamaria
AU - Inanc, Nevsun
AU - Juche, Aaron
AU - Karalilova, Rositsa
AU - Kawamoto, Toshio
AU - Keller, Kresten Krarup
AU - Keen, Helen Isobel
AU - Kermani, Tanaz A.
AU - Kohler, Minna J.
AU - Koster, Matthew
AU - Luqmani, Raashid Ahmed
AU - Macchioni, Pierluigi
AU - Mackie, Sarah Louise
AU - Naredo, Esperanza
AU - Nielsen, Berit Dalsgaard
AU - Ogasawara, Michihiro
AU - Pineda, Carlos
AU - Schäfer, Valentin Sebastian
AU - Seitz, Luca
AU - Tomelleri, Alessandro
AU - Torralba, Karina D.
AU - Van Der Geest, Kornelis S.M.
AU - Warrington, Kenneth J.
AU - Schmidt, Wolfgang A.
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37-0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.
AB - Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37-0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.
KW - giant cell arteritis
KW - outcome assessment, health care
KW - systemic vasculitis
KW - ultrasonography
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UR - http://www.scopus.com/inward/citedby.url?scp=85144887883&partnerID=8YFLogxK
U2 - 10.1136/ard-2022-223367
DO - 10.1136/ard-2022-223367
M3 - Article
C2 - 36600183
AN - SCOPUS:85144887883
SN - 0003-4967
VL - 82
SP - 556
EP - 564
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 4
ER -