The proto-oncogene c-fms is overexpressed in endometrial cancer

Gary S. Leiserowitz, Steven A. Harris, Malayannan Subramaniam, Gary L. Keeney, Karl C. Podratz, Thomas C. Spelsberg

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24 Scopus citations

Abstract

Recent studies have shown that macrophage colony-stimulating factor and its receptor c-fms protein are significantly overexpressed in endometrial and ovarian cancers. In the present study, we analyzed the steady-state levels of c-fms mRNA in benign and malignant endometrial tissues by Northern and slot blot analyses. The relative levels of c-fms mRNA were quantified by using a hybridization signal for each sample on Northern blot analysis. Slot blot analysis was used to further quantitate the relative increase in c-fms mRNA in malignant specimens compared to benign specimens. Correlation of c-fms expression in the endometrial cancers was made with traditional prognostic indicators. Secretory endometrium had low levels of c-fms mRNA, whereas the endometrial cancers had the highest levels. Proliferative and hyperplastic endometrium values were intermediate. Comparative assessment of c-fms expression in endometrial cancer relative to other prognostic factors demonstrated greater expression of c-fms in specimens from patients with abnormal DNA ploidy, high-grade lesions, and possibly extrauterine metastases. Our study confirms the overexpression of c-fms in endometrial cancer and demonstrates a positive correlation between the steady-state mRNA levels of c-fms and other select adverse prognostic indicators.

Original languageEnglish (US)
Pages (from-to)190-196
Number of pages7
JournalGynecologic oncology
Volume49
Issue number2
DOIs
StatePublished - May 1993

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Leiserowitz, G. S., Harris, S. A., Subramaniam, M., Keeney, G. L., Podratz, K. C., & Spelsberg, T. C. (1993). The proto-oncogene c-fms is overexpressed in endometrial cancer. Gynecologic oncology, 49(2), 190-196. https://doi.org/10.1006/gyno.1993.1106