The protective role of brain size in Alzheimer's disease

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Evaluation of: Perneczky R, Wagenpfeil S, Lunetta KL et al. Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease. Neurology 75, 137-142 (2010). The brain reserve hypothesis suggests that larger brain size is associated with a greater ability to tolerate pathological damage before showing any cognitive decline. This theory has been used to explain why many patients with Alzheimer's disease pathology are cognitively normal before death. However, the literature concerning the brain reserve hypothesis is mixed with evidence both for and against this theory. Perneczky and colleagues tested the theory by assessing whether premorbid brain size, measured using head circumference, alters the relationship between brain atrophy and cognitive decline in 270 Alzheimer's disease patients. They found that head circumference was associated with a reduced impact of atrophy on cognitive performance. Hence, for a given degree of atrophy, cognitive performance was better in patients with a larger head circumference. Therefore, these findings support the brain reserve hypothesis. This article will discuss the brain reserve concept and potential limitations and significance of this study.

Original languageEnglish (US)
Pages (from-to)1799-1801
Number of pages3
JournalExpert Review of Neurotherapeutics
Volume10
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Cognitive Reserve
Alzheimer Disease
Atrophy
Brain
Head
Aptitude
Neurology
Cognition
Pathology

Keywords

  • Alzheimer's disease
  • atrophy
  • brain reserve
  • cognition
  • head circumference

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)

Cite this

The protective role of brain size in Alzheimer's disease. / Whitwell, Jennifer Lynn.

In: Expert Review of Neurotherapeutics, Vol. 10, No. 12, 12.2010, p. 1799-1801.

Research output: Contribution to journalArticle

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