The prognostic value of N-terminal proB-type natriuretic peptide

Lisa C. Costello-Boerrigter, John C. Burnett

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

The heart is not only a pump, but also it is an endocrine organ. Cardiac stretch and overload stimulate the secretion of natriuretic peptides, which have a variety of beneficial actions, such as vasodilation and natriuresis. Cardiac-derived natriuretic peptides, especially B-type natriuretic peptide (BNP), have emerged as useful biomarkers for the diagnosis, and potentially the treatment, of heart failure patients. The inactive amino-terminal fragment of the BNP prohormone (NT-proBNP), which is more stable than mature BNP, has also been recognized as an aid in the diagnosis of left-ventricular systolic dysfunction. Furthermore, elevated NT-proBNP concentrations have been shown to be predictive of poor prognosis in a variety of cardiovascular diseases, suggesting that it could be useful for risk stratification of patients. This review summarizes current literature that has addressed the issue of NT-proBNP as a prognostic tool in heart failure, acute coronary syndromes and other conditions.

Original languageEnglish (US)
Pages (from-to)194-201
Number of pages8
JournalNature Clinical Practice Cardiovascular Medicine
Volume2
Issue number4
DOIs
StatePublished - Apr 1 2005

Keywords

  • B-type natriuretic peptide
  • Biomarkers
  • Diagnosis
  • N-terminal proB-type natriuretic peptide
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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